CD8+ T cells promote cytokine responses to stress

Clark, Sarah M.; Song, Chang; Li, Xin; Keegan, Achsah; Tonelli, Leonardo H.

doi:10.1016/j.cyto.2018.07.015

Cited by 18 publications

(13 citation statements)

References 42 publications

(55 reference statements)

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“…In rats and humans, corticosterone may cause choroidal thickening, a feature typical for patients with CSC (Zhao et al 2012). When psychologically stressed (a known risk factor for CSC), the body produces stress hormones such as cortisol, which are able to trigger IL‐6 release into the circulation (Clark et al 2019). Moreover, glucocorticoids were shown to enhance IL‐6‐dependent expression of pro‐inflammatory genes by inhibiting the suppressor of cytokine signalling 3, a physiological mechanism that controls acute inflammatory response (Dittrich et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Altered plasma cytokine levels in acute and chronic central serous chorioretinopathy

Karska‐Basta

Pociej‐Marciak

Chrząszcz

et al. 2020

Acta Ophthalmologica

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Purpose To evaluate plasma levels of selected cytokines and investigate their correlation with choroidal thickness (CT) in patients with acute and chronic central serous chorioretinopathy (CSC). Methods We enrolled 30 patients with acute CSC, 30 patients with chronic CSC and 20 controls. Plasma concentrations of 12 cytokines, interleukins IL‐8, IL‐1β, IL‐2, IL‐4, IL‐5, IL‐6, IL‐10 and IL‐12 p70, granulocyte‐macrophage colony‐stimulating factor, interferon‐γ, tumour necrosis factor‐α (TNF‐α) and vascular endothelial growth factor (VEGF), were measured using multiplex immunoassays. Differences in cytokine levels between groups were assessed. We also investigated correlations between cytokine levels and CT using swept‐source optical coherence tomography, as well as an association between plasma cytokine profile and systemic hypertension. Results We noted differences in IL‐6 (p = 0.005), IL‐10 (p = 0.03), IL‐12 p70 (p = 0.028) and VEGF (p = 0.029) levels between groups. Pro‐inflammatory IL‐12 p70 and multidirectional IL‐10 cytokines were upregulated, while pro‐angiogenic VEGF was downregulated in chronic CSC as compared with controls (p = 0.005, p = 0.025 and p = 0.027, respectively). Interleukin‐6 (IL‐6) was upregulated in acute and chronic CSC (p = 0.030 and p = 0.005, respectively). Interleukin‐5 (IL‐5), IL‐6 and IL‐12 levels correlated with mean CT in acute CSC (p = 0.008, p = 0.003 and p = 0.044, respectively), while IL‐8, IL‐6 and TNF‐α plasma levels correlated with hypertension in chronic CSC (p = 0.005, p = 0.033 and p = 0.001, respectively). Conclusion We provided new evidence for the possible role of plasma cytokines in the pathogenesis of CSC. Our results suggest that IL‐6 may be important in the pathophysiology of acute and chronic CSC. The association between inflammatory response and hypertension in patients with CSC was also confirmed.

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Section: Discussionmentioning

confidence: 99%

Altered plasma cytokine levels in acute and chronic central serous chorioretinopathy

Karska‐Basta

Pociej‐Marciak

Chrząszcz

et al. 2020

Acta Ophthalmologica

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“…Activation of the peripheral components of the HPA axis triggers the systemic production of glucocorticoids as an adaptive response to stress aiming to re-establish and maintain homeostasis [ 1 , 2 ]. While the chronic stress increases the activity of the HPA axis, with subsequent alteration of the neuroendocrine system [ 1 – 3 ] as well as the immune functions and cytokine profile [ 4 , 5 ]. The brain-derived neurotrophic factor (BDNF), whose primary role is in the process of neuroplasticity, is also involved in the stress circuitry.…”

Section: Introductionmentioning

confidence: 99%

Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students

Myint

Jacobs

Myint³

et al. 2021

PLoS ONE

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The effects of stress on the neuroendocrine, central nervous and immune systems are extremely complex. The kynurenine pathway (KP) of the tryptophan metabolism is recognised as a cross-link between the neuroendocrine- and immune systems. However, the effects of acute stress from everyday life on KP activation have not yet been studied. This study aims to investigate changes in the levels of the KP neuroactive metabolites and cytokines in response to stress triggered by academic examinations. Ninety-two healthy first year medical students benevolently participated in the study. Parameters were measured pre- examination, which is considered to be a high-stress period, and post-examination, as a low-stress period. Stress induced by academic examinations significantly increases the perceived stress scores (p<0.001), serum cortisol levels (p<0.001) and brain-derived neurotrophic factor (BDNF) levels (p<0.01). It decreased IL-10 levels (p<0.05) but had no effect on IL-6 and TNF-alpha levels. Only the KP neuroactive metabolite, 3-hydroxykynurenine (3-HK) significantly increased (p<0.01) in the post-examination period. In addition, the stress scores positively correlated with the levels of cortisol (r2 = 0.297, p<0.01) at post examination. Acute stress triggered by academic examinations increases cortisol and BDNF production and suppresses the anti-inflammatory cytokine, IL-10, but did not increase significantly the levels of other pro-inflammatory cytokines, tryptophan, kynurenine and downstream KP metabolites. The concomitant increased levels of BDNF under the duress of acute examination stress appear to limit the levels pro-inflammatory markers, which may attenuate the action of cortisol and the neuroinflammatory branch of the KP.

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“…The concentrations of TNF-α, proinflammatory cytokines, are expected to be increased in infection; however, its concentrations were significantly increased in children with RAP than that with parasitic infection. This may be explained by repeated and chronic psychological stress-induced pro-inflammatory cytokines production ( 11 , 15 , 56 , 57 ). The inflammatory markers, IL-1β and TNF-α are the most consistently reported cytokines responsible for psychological stress response regardless of stressors and species ( 11 , 58 ).…”

Section: Discussionmentioning

confidence: 99%

“…This may be explained by repeated and chronic psychological stress-induced pro-inflammatory cytokines production ( 11 , 15 , 56 , 57 ). The inflammatory markers, IL-1β and TNF-α are the most consistently reported cytokines responsible for psychological stress response regardless of stressors and species ( 11 , 58 ). The lower concentrations of TNF-α in this study cohort of children with parasitic infections may be due to their significantly higher concentrations of IL-10.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence has shown that these symptoms can be triggered by recent stressful life events ( 9 ) and emotional stress ( 5 ). It is well established that chronic stress has a significant impact on the hypothalamo-pituitary adrenal (HPA) axis ( 10 ) and also on the immune system through inducing the secretion of pro-inflammatory mediators ( 11 , 12 ). The evidence of stress- induced inflammation is well documented in young adults.…”

Section: Introductionmentioning

confidence: 99%

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Psychological Stresses in Children Trigger Cytokine- and Kynurenine Metabolite-Mediated Abdominal Pain and Proinflammatory Changes

Myint

Jacobs

Myint³

et al. 2021

Front. Immunol.

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Recurrent abdominal pain (RAP) is a common medically unexplained symptom among children worldwide. However, the biological mechanisms behind the development of functional and behavioral symptoms and changes in blood markers have not been well explored. This study aimed to assess changes in the concentrations of inflammatory markers, including cytokines and tryptophan catabolites, in the serum of children with RAP compared to those with subclinical infections. Children with RAP but without organic diseases were included, and those with asymptomatic intestinal parasitic infections were used as a subclinical infection cohort. Blood samples were collected and used to measure the cytokine profile using Multiplex Immunoassay and tryptophan catabolites using high performance liquid chromatography. Children with RAP showed significantly higher concentrations of serum tumor necrotic factor-α, p<0.05, but lower concentrations of IL-10, p<0.001, IL-6, p<0.001 and brain-derived neurotrophic factors (BDNF) p<0.01. In addition, a significant increase in the metabolite of the kynurenine pathway, 3-hydroxyanthranilic acid (3-HAA) p<0.01, a significant decrease in the concentrations of anthranilic acid (AA) p<0.001, together with an increased ratio of serum 3-HAA to AA (3-HAA/AA) p<0.001, was found in this cohort. These findings indicate the significant activation of the immune system and presence of inflammation in children with RAP than those with subclinical parasitic infections. Moreover, children with RAP tested with the Strengths and Difficulties Questionnaire (SDQ), displayed high psychological problems though these SDQ scores were not statistically associated with measured cytokines and kynurenine metabolites. We however could hypothesize that the pro-inflammatory state together with concomitant low concentrations of BDNF in those children with RAP could play a role in psychological stress and experiencing medically unexplained symptoms.

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CD8+ T cells promote cytokine responses to stress

Cited by 18 publications

References 42 publications

Altered plasma cytokine levels in acute and chronic central serous chorioretinopathy

Altered plasma cytokine levels in acute and chronic central serous chorioretinopathy

Effects of stress associated with academic examination on the kynurenine pathway profile in healthy students

Psychological Stresses in Children Trigger Cytokine- and Kynurenine Metabolite-Mediated Abdominal Pain and Proinflammatory Changes

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