CD8 T cell hyperfunction and reduced tumour control in models of advanced liver fibrosis
Jood Madani,
Jiafeng Li,
Agatha Vranjkovic
et al.
Abstract:Immune dysfunction, both depression and hyperactivation, in liver disease contributes to significant morbidities and mortalities, depending on liver damage severity and etiology. The underlying causes of immune dysfunction in advanced liver disease, whether pathogen or host-mediated, remain unclear. We reported lasting generalized CD8 T cell hyperfunction in individuals with advanced liver fibrosis in chronic HCV infection. The separation of viral and fibrosis-driven effects or the association of this phenomen… Show more
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