CD8 T-Cell Activation Is Associated With Lipodystrophy and Visceral Fat Accumulation in Antiretroviral Therapy–Treated Virologically Suppressed HIV-Infected Patients

Guaraldi, Giovanni; Luzi, Kety; Bellistrì, Giusi M.; Zona, Stefano; Silva, Ana Rita Domingues da; Bai, Francesca; Garlassi, Elisa; Marchetti, Giulia; Capeau, Jacqueline; Monforte, Antonella d’Arminio

doi:10.1097/qai.0000000000000001

Cited by 19 publications

(12 citation statements)

References 35 publications

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“…CD8+ T-cell activation is considered a less strong predictor of mortality and non-AIDS defining events in treated HIV infection than soluble immune activation markers [35, 36]. However, it has been associated with certain non-AIDS comorbidities, such as visceral fat accumulation and subclinical carotid artery disease [37, 38]. Our findings, though preliminary and obtained in a small group of patients, suggest that decreased T-cell activation might contribute to mediate exercise-induced health benefit.…”

Section: Discussionmentioning

confidence: 99%

A pilot study of brisk walking in sedentary combination antiretroviral treatment (cART)- treated patients: benefit on soluble and cell inflammatory markers

et al. 2017

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BackgroundChronic HIV infection is associated with low-level inflammation and increased risk of chronic diseases and mortality. The objective was to assess the effects of moderate intensity exercise on metabolic and inflammatory markers in HIV-infected treated persons.MethodsThis was a pilot study enrolling cART-treated, sedentary persons with metabolic complications in a 12-week protocol, consisting of three sessions per week of 60 min brisk walking with (strength-walk group) or without (walk group) 30 min circuit-training. Assessments at baseline and week 12 (W12) included body morphometrics and total body dual-energy X-ray absorptiometry; lipid and glucose blood profile; plasma level of high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), D-dimer, interleukin-18 (IL-18), soluble CD14, and CD38 and HLA-DR expression on CD4+ and CD8+ T-cells.ResultsForty-nine patients were included and 35 (71%) completed the program: 21 in the walk and 14 in the strength-walk group. At W12, significant improvements were observed of body mass index, waist and hip circumference, and total cholesterol both overall and in the walk group, and of LDL cholesterol in both training groups. In the whole group, significant reductions were observed in hsCRP, IL-6, D-dimer, IL-18, and of CD8+/CD38+/HLA-DR+ cell frequencies. HsCRP and CD8+/CD38+/HLA-DR+ frequency decreased significantly in both training groups when examined separately whereas IL-6 and D-dimer in the walk group only.ConclusionsBrisk walking, with or without strength exercise, could improve lipid profile and inflammatory markers in chronic HIV infection.Trial registrationACTRN12615001258549, registered 17 November 2015, “retrospectively registered” Web address of trial: http://www.ANZCTR.org.au/ACTRN12615001258549.aspx Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-2095-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A pilot study of brisk walking in sedentary combination antiretroviral treatment (cART)- treated patients: benefit on soluble and cell inflammatory markers

et al. 2017

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“…These findings are consistent with previous studies which have suggested that peripheral fat loss is mainly affected by HIV immune dysregulation, specifically high levels of CD8 + T-cell activation. 5,8 …”

Section: Discussionmentioning

confidence: 99%

CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population

Riangwiwat

Kohorn

Chow

et al. 2016

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…HIV-associated chronic inflammation and immune activation may play a role in the development of visceral adiposity, with circulating CD8 + T lymphocyte activation linked to VAT accumulation[53]. Activation of the renin-angiotensin system has been independently associated with treated HIV infection and VAT accumulation[54, 55], and appears to independently predict insulin resistance[56].…”

Section: Consequences Of Obesity and Visceral Adipositymentioning

confidence: 99%

The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection

Lake

2017

Curr HIV/AIDS Rep

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Purpose of Review To summarize knowledge of the prevalence, relevant physiology and consequences of obesity and visceral adiposity in HIV-infected adults, including highlighting gaps in current knowledge and future research directions. Recent Findings Similar to the general population, obesity prevalence is increasing among HIV-infected persons, and obesity and visceral adiposity are associated with numerous metabolic and inflammatory sequelae. However, HIV- and antiretroviral therapy (ART)-specific factors may contribute to fat gain and fat quality in treated HIV infection, particularly to the development of visceral adiposity, and sex differences may exist. Summary Obesity and visceral adiposity commonly occur in HIV-infected persons and have significant implications for morbidity and mortality. Future research should aim to better elucidate the HIV- and ART-specific contributors to obesity and visceral adiposity in treated HIV infection, with the goal of developing targeted therapies for the prevention and treatment of obesity and visceral adiposity in the modern ART era.

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CD8 T-Cell Activation Is Associated With Lipodystrophy and Visceral Fat Accumulation in Antiretroviral Therapy–Treated Virologically Suppressed HIV-Infected Patients

Cited by 19 publications

References 35 publications

A pilot study of brisk walking in sedentary combination antiretroviral treatment (cART)- treated patients: benefit on soluble and cell inflammatory markers

A pilot study of brisk walking in sedentary combination antiretroviral treatment (cART)- treated patients: benefit on soluble and cell inflammatory markers

CD4/CD8 Ratio Predicts Peripheral Fat in HIV-Infected Population

The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection

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