CD8-positives, CD30-negatives kutanes T-Zell-Lymphom unter dem klinischen Bild eines Pyoderma gangraenosum

Abstract

Ulcerated primary cutaneous lymphomas are not rare, but the clinical manifestation as a pyoderma gangrenosum look-alike is extraordinary. CD8-positive lymphomas are rare, unclassifiable tumours with variable prognosis. We report on a 49-year-old patient with a large ulcerated primary cutaneous lymphoma on the left chest wall presenting as pyoderma gangrenosum. With immunohistochemical staining, most lymphocytes were shown to be CD8-positive. The CD30 antigen was not expressed. After radiotherapy with complete skin irradiation, the lymphoma regressed completely. The patient has been free of relapse for 28 months so far.

CD8-positive mycosis fungoides masquerading as pyoderma gangrenosum

“…[ 4 ] Our case mimicked pyoderma gangrenosum. Till date, there is only a single report of CD8+ MF mimicking pyoderma gangrenosum[ 5 ] in the English literature, to the best of our knowledge. However, there are few reports of other CTCLs resembling pyoderma gangrenosum.…”

Multiple lesions of pyoderma gangrenosum in association with hyper-reactive malarial splenomegaly

“…A recent paper describes PG as a complication of non‐Hodgkin's lymphoma, 6 and another reports the development of Hodgkin's lymphoma in patients with PG 7 . In addition, it is currently accepted that PG‐like ulcers may be an atypical clinical manifestation in cutaneous lymphoma 8,9 …”