CD8+ lymphocytes and apoptosis in typical and atypical medullary carcinomas of the breast

Diagnostic significance of intratumoral CD8+ tumor-infiltrating lymphocytes in medullary carcinoma

“…High levels of CD8+ TIL infiltration are well known to be associated with more favorable outcomes for patients with various types of cancer, and scoring of CD8+ TILs is thought to be a promising standard for evaluating the malignant potential of sporadic cancers [19,20]. Prior studies found that the majority of TILs in MCs are mature T-cells comprised mainly of CD8+ TILs, suggesting the existence of a cytotoxic immune reaction against malignant cells [21][22][23].…”

Inflammatory Hepatic Carcinomas

“…In the breast, medullary carcinoma is a member of the so-called basal group which has been classified as tumors with a favorable prognosis in several studies, notwithstanding its high-grade morphology (Rakha et al 2009;Cao et al 2013), mainly in patients with so-called typical medullary carcinoma (Nurlaila et al 2013), but there are also investigations that found no difference in outcome in comparison with invasive ductal carcinoma (Park et al 2013). The downregulation of genes involved in cellular proliferation, an effective host immune response, enhanced tumor cell apoptosis, and elevated levels of metastasisinhibiting and low levels of metastasis-promoting factors were suggested to account for the better prognosis (Yakirevich et al 1999;Bertucci et al 2006;Weigelt et al 2008).…”

Иммунофармакологические Свойства Нового Производного 5-Оксипиримидина Снк-411

“…Àíòèãåí-àêòèâèðîâàííûå ÖÒË ëèçèðóþò îïóõîëå-âûå êëåòêè ÷åðåç âûñâîáîaeäåíèå ïåðôîðèíîâ, ëèáî çàïóñêàþò ïðîãðàììèðîâàííóþ êëåòî÷íóþ ãèáåëü îïóõîëåâûõ êëåòîê ïî ïóòè Fas/FasL [11].…”