CD8+CD45RA+CD27-CD28-T-cell subset in PBL of cervical cancer patients representing CD8+T-cells being able to recognize cervical cancer associated antigens provided by HPV 16 E7

Pilch, Henryk; Hoehn, Hannah J.; Schmidt, Monika; Steiner, E.; Berno, Tamara; Seufert, R.; Maeurer, Markus

doi:10.1055/s-2002-38130

Cited by 17 publications

(11 citation statements)

References 12 publications

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“…Similarly, a population of TNFa-producing CD8 þ CD28 -T cells has been reported in patients with cervical cancer (85). Expanded populations of CD8 þ CD28 -T cells are present in ankylosing spondylitis patients, and, in fact, correlate with a more severe course of this autoimmune disease (95).…”

Section: Senescent Cd8 þ T Cells Have Regulatory Roles In Vivomentioning

confidence: 88%

“…The apoptosis resistance of these cells leads to a situation where they occupy progressively more and more of the memory T‐cell pool in the elderly, restricting the repertoire of the remaining T cells. Latent viruses associated with certain forms of cancer can also drive CD8 + T cells to senescence, as illustrated by the accumulation in cervical cancer patients of CD8 + CD28 – T cells with reactivity to human papillomavirus E7 antigen (85).…”

Section: Antigen Specificity Of Senescent T Cells That Arise In Vivomentioning

confidence: 99%

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The role of CD8⁺ T‐cell replicative senescence in human aging

Effros

Dagarag

Spaulding

et al. 2005

Immunological Reviews

304

273

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The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity. CD8(+) T cells that undergo extensive rounds of antigen-driven proliferation in cell culture invariably reach the end stage of replicative senescence, characterized by irreversible cell-cycle arrest and a critically short telomere length. Cultures of senescent CD8(+) T cells also show resistance to apoptosis, permanent loss of CD28 expression, altered cytokine profiles, reduced ability to respond to stress, and various functional changes. Cells with similar characteristics accumulate during normal aging as well as in younger persons infected with human immunodeficiency virus, suggesting that the process of replicative senescence is not an artifact of cell culture but is also occurring in vivo. Interestingly, in elderly persons, the presence of high proportions of CD8(+) T cells with characteristics of replicative senescence is correlated with reduced antibody responses to vaccines as well as with osteoporotic fractures. CD8(+)CD28(-) T cells also accumulate in patients with certain types of cancer. The emerging picture is that senescent CD8(+) T cells may modulate both immune and non-immune functions, contributing not only to reduced anti-viral immunity but also to diverse age-related pathologies.

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Section: Senescent Cd8 þ T Cells Have Regulatory Roles In Vivomentioning

confidence: 88%

Section: Antigen Specificity Of Senescent T Cells That Arise In Vivomentioning

confidence: 99%

The role of CD8⁺ T‐cell replicative senescence in human aging

Effros

Dagarag

Spaulding

et al. 2005

Immunological Reviews

304

273

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“…The loss of CD27 and CD28 in T cells has also been correlated with their function as cytotoxic immune effectors (32). Interestingly, unlike in the peripheral blood where CD27 and CD28 loss is a poor prognostic indicator in the tumor microenvironment, the opposite has been shown (33,34). A potential explanation is that patients with a better prognosis have higher rates of TIL-TIS, whereas those with a poorer prognosis have a more aggressive cancer leading to TIA.…”

Section: Discussionmentioning

confidence: 99%

Tumor-Induced Senescent T Cells with Suppressor Function: A Potential Form of Tumor Immune Evasion

Montes¹,

Chapoval²,

Nelson³

et al. 2008

Cancer Research

103

129

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Senescent and suppressor T cells are reported to be increased in select patients with cancer and are poor prognostic indicators. Based on the association of these T cells and poor outcomes, we hypothesized that tumors induce senescence in T cells, which negatively effects antitumor immunity. In this report, we show that human T cells from healthy donors incubated with tumor for only 6 h at a low tumor to T-cell ratio undergo a senescence-like phenotype, characterized by the loss of CD27 and CD28 expression and telomere shortening. Tumor-induced senescence of T cells is induced by soluble factors and triggers increases in expression of senescence-associated molecules such as p53, p21, and p16. Importantly, these T cells are not only phenotypically altered, but also functionally altered as they can suppress the proliferation of responder T cells. This suppression requires cell-to-cell contact and is mediated by senescent CD4 + and CD8 + subpopulations, which are distinct from classically described natural T regulatory cells. Our observations support the novel concept that tumor can induce senescent T cells with suppressor function and may effect both the diagnosis and treatment of cancer. [Cancer Res 2008;68(3):870-9]

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“…One prime example, demonstrated in three recent independent studies, indicates that poor responsiveness to influenza vaccination is significantly associated with the presence of high proportions of a population of CD8 + T lymphocytes that lack expression of the co-stimulatory molecule CD28 [2,3,4] (also see the article by Weng et al in this issue). Moroever, associations have been described between high proportions of CD8 + CD28 − cells and the prevention of allograft rejection [5], accelerated progression of HIV-1 infection [6], head and neck tumors [7], cervical cancer [8], ankylosing spondylitis [9], and other diseases involving an inflammatory state; suggesting a generalized suppressor function. Of note, this same biomarker is part of a cluster of immune parameters, the so-called ‘immune risk phenotype’, that are associated with early mortality in longitudinal studies of the elderly [10].…”

Section: Mechanisms Leading To Immunosenescencementioning

confidence: 99%

Vaccination in the elderly: an immunological perspective

Chen

Kozlovsky

Effros

et al. 2009

Trends in Immunology

224

187

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Successful vaccination of the elderly against important infectious pathogens which cause high morbidity and mortality represents a growing public health priority. Building upon the theme of aging and immunosenescence, we review mechanisms of human immunosenescence and the immune response to currently-licensed vaccines. We discuss the difficulties in identifying the risk factors that, in addition to aging, cause immunosenescence and address the relative paucity of vaccine studies in the elderly. We conclude that vaccine responses are blunted in the elderly when compared to that of healthy young adults. However, it is also clear that our understanding of the mechanisms underlying immunosenescence is limited and much remains to be learned in order to improve the effectiveness of next generation vaccines.

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CD8+CD45RA+CD27-CD28-T-cell subset in PBL of cervical cancer patients representing CD8+T-cells being able to recognize cervical cancer associated antigens provided by HPV 16 E7

Abstract: The sorting of CD8+CD45RA+CD28-T-cells enables to determine the fine specificity of CD8+ effector T-cells without the need for in vitro manipulation and aids to define the most appropriate target epitopes for novel vaccine designs.

Cited by 17 publications

References 12 publications

The role of CD8⁺ T‐cell replicative senescence in human aging

The role of CD8⁺ T‐cell replicative senescence in human aging

Tumor-Induced Senescent T Cells with Suppressor Function: A Potential Form of Tumor Immune Evasion

Vaccination in the elderly: an immunological perspective

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CD8+CD45RA+CD27-CD28-T-cell subset in PBL of cervical cancer patients representing CD8+T-cells being able to recognize cervical cancer associated antigens provided by HPV 16 E7

Abstract: The sorting of CD8+CD45RA+CD28-T-cells enables to determine the fine specificity of CD8+ effector T-cells without the need for in vitro manipulation and aids to define the most appropriate target epitopes for novel vaccine designs.

Cited by 17 publications

References 12 publications

The role of CD8+ T‐cell replicative senescence in human aging

The role of CD8+ T‐cell replicative senescence in human aging

Tumor-Induced Senescent T Cells with Suppressor Function: A Potential Form of Tumor Immune Evasion

Vaccination in the elderly: an immunological perspective

Contact Info

Product

Resources

About

The role of CD8⁺ T‐cell replicative senescence in human aging

The role of CD8⁺ T‐cell replicative senescence in human aging