CD73-Mediated Liberation of Adenosine Protects Intestinal Epithelial Cells From C. difficile Toxin-Induced Damage

Schenck, L. Patrick; Hirota, Simon A.; Potentier, Mireille S.; Li, Yan; Armstrong, Glen D.; Beck, Paul L.; MacDonald, Justin A.

doi:10.1016/s0016-5085(11)62059-3

Cited by 1 publication

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“…Clostridium difficile causes widespread infection by releasing toxins that break down epithelial tight junctions and compromising the intestinal epithelial barrier. CD73-mediated liberation of adenosine has been shown to protect intestinal epithelial cells from C. difficile toxininduced damage [607]. Neurotensin stimulates Cl − secretion in human colonic mucosae, involving mucosal nerves, adenosine and prostaglandins [579].…”

Section: Intestinal Secretionmentioning

confidence: 99%

Purinergic signalling in the gastrointestinal tract and related organs in health and disease

Burnstock

2013

Purinergic Signalling

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Purinergic signalling plays major roles in the physiology and pathophysiology of digestive organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive intestinal peptide, is a cotransmitter in nonadrenergic, non-cholinergic inhibitory neuromuscular transmission. P2X and P2Y receptors are widely expressed in myenteric and submucous enteric plexuses and participate in sympathetic transmission and neuromodulation involved in enteric reflex activities, as well as influencing gastric and intestinal epithelial secretion and vascular activities. Involvement of purinergic signalling has been identified in a variety of diseases, including inflammatory bowel disease, ischaemia, diabetes and cancer. Purinergic mechanosensory transduction forms the basis of enteric nociception, where ATP released from mucosal epithelial cells by distension activates nociceptive subepithelial primary afferent sensory fibres expressing P2X3 receptors to send messages to the pain centres in the central nervous system via interneurons in the spinal cord. Purinergic signalling is also involved in salivary gland and bile duct secretion.

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Section: Intestinal Secretionmentioning

confidence: 99%