Immunological impact of the CD71+ RBCs: A potential immune mediator in transfusion

Li, Wenhui; Acker, Jason P.

doi:10.1016/j.transci.2023.103721

Cited by 1 publication

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“…CECs also suppress the production of TNF-α production from both macrophages and antigen-presenting cells. Additionally, CECs can suppress T cell proliferation [12]. It is stated that CECs can be used as a prognostic marker in sepsis due to their immunosuppressive effects [13].…”

Section: Discussionmentioning

confidence: 99%

Importance of CD71⁺ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

Görgülügil,

Uğur Kurtoğlu,

Uğur

et al. 2024

Clinical Laboratory Analysis

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Background/ObjectivesCD71+ erythroid cells (CECs) are immature red blood cells (proerythroblasts, erythroblasts, and reticulocytes). CECs play an important role in the development of sepsis and cancer by causing immunosuppression. We examined the CEC levels in the peripheral blood of beta thalassemia (βThal) patients and investigated the relationship between CECs and the clinical status of the patients, especially splenectomy.MethodsSixty‐eight patients with βThal (46 splenectomized and 22 nonsplenectomized) and 15 healthy controls were included in this study. The hemogram parameters, ferritin, and CECs (flow cytometry method) were measured.ResultsIt was observed that the CEC level in the patient group was significantly higher than the control group (p < 0.05). CEC levels were found to be significantly higher in patients with splenectomy than in patients with nonsplenectomy (p < 0.05). CEC levels were higher in patients with nontransfusion‐dependent βT (NTD‐βThal) than in patients with transfusion‐dependent βT (TD‐βThal) (p < 0.05). CEC levels were found to be significantly higher in patients with splenectomy than in patients with nonsplenectomy in both TD‐βThal and NTD‐βThal groups (p < 0.05). There was a moderate‐negative correlation was detected between CECs and Hb levels (r = −0.467; p < 0.05).ConclusionsHigh CEC levels in βThal patients develop as a result of ineffective erythropoiesis. We think that keeping CEC levels under control is important for prognosis, especially in patients with splenectomy.

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Section: Discussionmentioning

confidence: 99%

Importance of CD71⁺ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

Görgülügil,

Uğur Kurtoğlu,

Uğur

et al. 2024

Clinical Laboratory Analysis

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Immunological impact of the CD71+ RBCs: A potential immune mediator in transfusion

Cited by 1 publication

References 83 publications

Importance of CD71⁺ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

Importance of CD71⁺ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

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Immunological impact of the CD71+ RBCs: A potential immune mediator in transfusion

Cited by 1 publication

References 83 publications

Importance of CD71+ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

Importance of CD71+ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

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Importance of CD71⁺ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia

Importance of CD71⁺ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia