CD6 deficiency impairs early immune response to bacterial sepsis

Català, Cristina; Andrés, María Velasco-de; Leyton-Pereira, Alejandra; Casadó-Llombart, Sergi; Moya, Manuel Sáez; Gutiérrez-Cózar, Rebeca; Garcia-Luna, Joaquín; Consuegra-Fernández, Marta; Isamat, Marcos; Aranda, Fernando; Martínez-Florensa, Mario; Engel, Pablo; Mourglia‐Ettlin, Gustavo; Lozano, Francisco

doi:10.1016/j.isci.2022.105078

Cited by 3 publications

(3 citation statements)

References 58 publications

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“…Given the multifaceted nature of CD6, the above-mentioned mechanistic findings for exacerbated symptoms during DSS colitis in Cd6 -/- mice do not exclude other possibilities such as decreased Treg functionality in Cd6 -/- mice ( 59 ), a cell subset known for its role in mucosal protection during DSS-induced colitis ( 66 ). Another possibility could be the deficient production of natural antibodies, as found in Cd6 -/- mice from DBA-1 background ( 60 ), and confirmed by us in the C57BL/6 background Cd6 -/- mice used here ( 67 ). Natural antibodies are an innate component of humoral immunity and have a protective role in IBD ( 68 , 69 ).…”

Section: Discussionsupporting

confidence: 74%

Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease

et al. 2022

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Crohn’s disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) resulting from the interaction of multiple environmental, genetic and immunological factors. CD5 and CD6 are paralogs encoding lymphocyte co-receptors involved in fine-tuning intracellular signals delivered upon antigen-specific recognition, microbial pattern recognition and cell adhesion. While CD5 and CD6 expression and variation is known to influence some immune-mediated inflammatory disorders, their role in IBD remains unclear. To this end, Cd5- and Cd6-deficient mice were subjected to dextran sulfate sodium (DSS)-induced colitis, the most widely used experimental animal model of IBD. The two mouse lines showed opposite results regarding body weight loss and disease activity index (DAI) changes following DSS-induced colitis, thus supporting Cd5 and Cd6 expression involvement in the pathophysiology of this experimental IBD model. Furthermore, DNA samples from IBD patients of the ENEIDA registry were used to test association of CD5 (rs2241002 and rs2229177) and CD6 (rs17824933, rs11230563, and rs12360861) single nucleotide polymorphisms with susceptibility and clinical parameters of CD (n=1352) and UC (n=1013). Generalized linear regression analyses showed association of CD5 variation with CD ileal location (rs2241002CC) and requirement of biological therapies (rs2241002C-rs2229177T haplotype), and with poor UC prognosis (rs2241002T-rs2229177T haplotype). Regarding CD6, association was observed with CD ileal location (rs17824933G) and poor prognosis (rs12360861G), and with left-sided or extensive UC, and absence of ankylosing spondylitis in IBD (rs17824933G). The present experimental and genetic evidence support a role for CD5 and CD6 expression and variation in IBD’s clinical manifestations and therapeutic requirements, providing insight into its pathophysiology and broadening the relevance of both immunomodulatory receptors in immune-mediated disorders.

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Section: Discussionsupporting

confidence: 74%

Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease

et al. 2022

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“…Eleven pathways are active only in GF mice, and these include pathways important for angiogenesis processes such as ESAM [33] , [47] and VEGF [22] . Eight pathways are specifically active in SPF mice, and these include known immune regulators such as CD6 [11] , [53] and IL16 [23] . Both MHC- I and MHC- II were significantly decreased in GF mice, which suggests that GF mice may have an immune defect [15] , [40] , [50] .…”

Section: Resultsmentioning

confidence: 99%

Single-cell and spatiotemporal transcriptomic analyses reveal the effects of microorganisms on immunity and metabolism in the mouse liver

Zhao

Cheng

Shen

et al. 2023

Computational and Structural Biotechnology Journal

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“…(4) Skin and soft tissue infection [5], such as cellulitis and furuncle, which can lead to sepsis in severe cases. (5) Blood infection [6], such as sepsis and septic shock, which is a critical condition with a high fatality rate. Bacterial infections are harmful because they can cause serious illness that deteriorates rapidly, posing a serious threat to the patient's health.…”

Section: Introduction 1bacterial Infections and Their Drug Resistancementioning

confidence: 99%

Controllable Preparation and Research Progress of Photosensitive Antibacterial Complex Hydrogels

Wang

Liu

et al. 2023

Gels

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Hydrogels are materials consisting of a network of hydrophilic polymers. Due to their good biocompatibility and hydrophilicity, they are widely used in biomedicine, food safety, environmental protection, agriculture, and other fields. This paper summarizes the typical complex materials of photocatalysts, photosensitizers, and hydrogels, as week as their antibacterial activities and the basic mechanisms of photothermal and photodynamic effects. In addition, the application of hydrogel-based photoresponsive materials in microbial inactivation is discussed, including the challenges faced in their application. The advantages of photosensitive antibacterial complex hydrogels are highlighted, and their application and research progress in various fields are introduced in detail.

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CD6 deficiency impairs early immune response to bacterial sepsis

Cited by 3 publications

References 58 publications

Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease

Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease

Single-cell and spatiotemporal transcriptomic analyses reveal the effects of microorganisms on immunity and metabolism in the mouse liver

Controllable Preparation and Research Progress of Photosensitive Antibacterial Complex Hydrogels

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