CD56brightCD16- to CD57+CD56dimCD16+ NK cell ratio discriminates disease activity and renal involvement in patients with systemic lupus erythematosus

Li, Hui; Geng, Linyu; Cao, Zhouli; Jin, Ziyi; Yan, Qing; Long, Xianming; Zhang, XueYi; De-sheng, Meng; Jiang, Yahui; Li, Wenchao; Sun, Lingyun

doi:10.55563/clinexprheumatol/o6bjl8

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“…However, an increase in the number of CD57 + CD16 + cells has been shown in tissues, such as the skin, joints, and pancreas, of affected individuals. Increased oxidative stress in patients with SLE may have caused preferential apoptosis of mature CD56 dim CD57 + NK cells, perhaps contributing to the impairment of the ability to eliminate pathogenic CD4 + T cells seen in SLE [ 53 , 83 , 90 , 106 ]. This impairment in the number and cytotoxic capacity of CD57 + CD16 + NK cells may be due to various mechanisms that different pathogens employ in the induction of some autoimmune diseases.…”

Section: Natural Killer (Nk) Cells and Their Subpopulationsmentioning

confidence: 99%

“…Autoimmune disease including celiac disease: early stages and full-blown [ 48 , 57 , 60 , 61 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 90 , 91 , 92 , 93 , 106 , 115 , 125 , 126 , 129 , 135 , 136 , 137 , 138 , 139 , 143 , 146 , 231 , 232 , 233 , 234 , 235 ];…”

Section: Potential Clinical and Therapeutic Applications Of Nk And Cd...mentioning

confidence: 99%

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Natural Killer Cells and Cytotoxic T Cells: Complementary Partners against Microorganisms and Cancer

Vojdani,

Koksoy,

Vojdani

et al. 2024

Microorganisms

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Natural killer (NK) cells and cytotoxic T (CD8+) cells are two of the most important types of immune cells in our body, protecting it from deadly invaders. While the NK cell is part of the innate immune system, the CD8+ cell is one of the major components of adaptive immunity. Still, these two very different types of cells share the most important function of destroying pathogen-infected and tumorous cells by releasing cytotoxic granules that promote proteolytic cleavage of harmful cells, leading to apoptosis. In this review, we look not only at NK and CD8+ T cells but also pay particular attention to their different subpopulations, the immune defenders that include the CD56+CD16dim, CD56dimCD16+, CD57+, and CD57+CD16+ NK cells, the NKT, CD57+CD8+, and KIR+CD8+ T cells, and ILCs. We examine all these cells in relation to their role in the protection of the body against different microorganisms and cancer, with an emphasis on their mechanisms and their clinical importance. Overall, close collaboration between NK cells and CD8+ T cells may play an important role in immune function and disease pathogenesis. The knowledge of how these immune cells interact in defending the body against pathogens and cancers may help us find ways to optimize their defensive and healing capabilities with methods that can be clinically applied.

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Section: Natural Killer (Nk) Cells and Their Subpopulationsmentioning

confidence: 99%

Section: Potential Clinical and Therapeutic Applications Of Nk And Cd...mentioning

confidence: 99%

Natural Killer Cells and Cytotoxic T Cells: Complementary Partners against Microorganisms and Cancer

Vojdani,

Koksoy,

Vojdani

et al. 2024

Microorganisms

View full text Add to dashboard Cite

show abstract

CD56brightCD16- to CD57+CD56dimCD16+ NK cell ratio discriminates disease activity and renal involvement in patients with systemic lupus erythematosus

Cited by 1 publication

References 0 publications

Natural Killer Cells and Cytotoxic T Cells: Complementary Partners against Microorganisms and Cancer

Natural Killer Cells and Cytotoxic T Cells: Complementary Partners against Microorganisms and Cancer

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