CD56 (Neural Cell Adhesion Molecule) Expression in Ovarian Carcinomas: Association With High-Grade and Advanced Stage But Not With Neuroendocrine Differentiation

Bösmüller, Hans; Wagner, Philipp; Pham, Deborah Lan; Fischer, Anna; Greif, Karen F.; Beschorner, Christine; Sipos, Bence; Fend, Falko; Staebler, Annette

doi:10.1097/igc.0000000000000888

Cited by 19 publications

(18 citation statements)

References 21 publications

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“…CD56, or neural cell adhesion molecule (N‐CAM), has been demonstrated on the membrane of a wide range of human cells, including natural killer cells and T lymphocytes, epithelium of the thyroid, kidney, and adrenal cortex, as well as skeletal muscle and neuroendocrine tissues (17). Despite its high sensitivity for neuroendocrine differentiation, CD56 can show positivity in a plethora of diverse neoplasms, substantially limiting its specificity (17–23). INSM1, an increasingly recognized neuroendocrine marker, represents a zinc‐finger transcription factor, first identified in pancreatic insulinoma (24).…”

Section: Figurementioning

confidence: 99%

The panel of syntaxin 1 and insulinoma‐associated protein 1 outperforms classic neuroendocrine markers in pulmonary neuroendocrine neoplasms

Zombori

Turkevi-Nagy

Sejben

et al. 2021

APMIS

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Syntaxin‐1 (STX1) is a recently described highly sensitive and specific neuroendocrine marker. We evaluated the applicability of STX1 as an immunohistochemical marker in pulmonary neuroendocrine neoplasms (NENs). We compared STX1 with established neuroendocrine markers, including insulinoma‐associated protein 1 (INSM1). Typical carcinoids (n = 33), atypical carcinoids (n = 7), small cell lung carcinomas ([SCLCs] n = 30), and large cell neuroendocrine lung carcinomas (n = 17) were immunostained using tissue microarray for STX1, chromogranin A, synaptophysin, CD56, and INSM1. Eighty‐four of eighty‐seven (96.5%) NENs showed STX1 positivity. Carcinoids and LCNECs typically presented a combined strong membranous and weak cytoplasmic staining pattern; cytoplasmic expression was predominately observed in SCLCs. The sensitivity of STX1 was 90% in SCLCs and 100% in typical carcinoids, atypical carcinoids, and large cell neuroendocrine lung carcinomas. The overall sensitivity of STX1 in pulmonary NENs was 96.6%, and the sensitivity of the other markers was as follows: chromogranin A (85.2%), synaptophysin (85.2%), CD56 (92.9%), and INSM1 (97.7%). STX1 was found to be an excellent neuroendocrine marker of pulmonary NENs, with sensitivity and specificity surpassing that of classic markers. We propose a panel of STX1 and INSM1 for the routine immunohistochemical workup of pulmonary NENs.

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Section: Figurementioning

confidence: 99%

The panel of syntaxin 1 and insulinoma‐associated protein 1 outperforms classic neuroendocrine markers in pulmonary neuroendocrine neoplasms

Zombori

Turkevi-Nagy

Sejben

et al. 2021

APMIS

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“…Interestingly, the calcification in our case was positive for ER, which occurs commonly in serous papillary carcinoma but generally not in WDPM [23,33]. In addition, the lack of D2-40 or CK5/6 would indicate serous papillary carcinoma over WDPM [4,5,34,35,37]. The minimal positivity for CD56 in our case also points towards PSC [37] versus WDPM or RMH [36] (Table 2).…”

Section: Discussionmentioning

confidence: 48%

“…In addition, the lack of D2-40 or CK5/6 would indicate serous papillary carcinoma over WDPM [4,5,34,35,37]. The minimal positivity for CD56 in our case also points towards PSC [37] versus WDPM or RMH [36] (Table 2). This case highlights the importance of the described stain selections.…”

Section: Discussionmentioning

confidence: 52%

Well-Differentiated Papillary Mesothelioma with Omental Calcifications: A Case Report and Review of the Literature

Erem¹,

Allamaneni

Braverman

2020

Am J Case Rep

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Rare co-existance of disease or pathology Background:Omental calcifications of the peritoneum are typically small and asymptomatic. However, larger psammomatous bodies that cause symptoms such as abdominal pain and bloating are often associated with tumors such as primary serous papillary carcinoma, mesothelioma, or metastatic ovarian cancer. Case Report:We describe omental calcifications in a 68-year-old woman who had been asymptomatic for the last 10 years.The case details the histomorphologic features and immunohistochemical signature of a 4.0×3.5×1.0 cm mass consisting of mature adipose tissue that was surgically removed together with an 8.5×6.5×1.8 cm irregular intra-abdominal/mesenteric mass composed of yellow-red fatty tissue. Microscopic sections contained fat with variable clustered classic/psammomatous calcifications, some with a thin epithelioid periphery, in association with a very focal and subtle papillary surface epithelial/mesothelial proliferation. Tumor cell invasion was not observed during examination. Immunohistochemical staining showed that mesothelial cells in the mass were strongly positive for calretinin and focally positive for EMA, CK903, and vimentin. Strong nuclear positivity for PAX8 was also reported. Additional stains were added in response to this pattern, showing strong positivity for CK8, moderate positivity for BAP1, focal positivity for ER, minimal positivity for CD56, and negativity for CK5/6 and D2-40. Three possible explanations are suggested for the phenomenon observed in the pathology slides: reactive mesothelial hyperplasia, well-differentiated papillary mesothelioma, or serous papillary carcinoma of the peritoneum. Conclusions:Findings suggest that these calcifications are a benign, reactive phenomenon, and that the abundance of psammoma bodies may be related to ongoing crops of papillary mesothelial hyperplasia or benign well-differentiated papillary mesothelioma.

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“…As shown here, CD56 homodimerization is an important interaction among neuroblastoma cells. It is, therefore, likely that such connections exist among more types of CD56-expressing malignancies, including ovarian carcinomas [46], renal neoplasms [47], and small-cell lung cancer [48]. Conceivably, CD56 homodimers may be involved in the adhesion among cancer cells, and implicated in the communication and organization within the tumor micro-environment [49].…”

Section: Discussionmentioning

confidence: 99%

CD56 Homodimerization and Participation in Anti-Tumor Immune Effector Cell Functioning: A Role for Interleukin-15

Acker

Versteven

et al. 2019

Cancers

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A particularly interesting marker to identify anti-tumor immune cells is the neural cell adhesion molecule (NCAM), also known as cluster of differentiation (CD)56. Namely, hematopoietic expression of CD56 seems to be confined to powerful effector immune cells. Here, we sought to elucidate its role on various killer immune cells. First, we identified the high motility NCAM-120 molecule to be the main isoform expressed by immune cells. Next, through neutralization of surface CD56, we were able to (1) demonstrate the direct involvement of CD56 in tumor cell lysis exerted by CD56-expressing killer cells, such as natural killer cells, gamma delta (γδ) T cells, and interleukin (IL)-15-cultured dendritic cells (DCs), and (2) reveal a putative crosstalk mechanism between IL-15 DCs and CD8 T cells, suggesting CD56 as a co-stimulatory molecule in their cell-to-cell contact. Moreover, by means of a proximity ligation assay, we visualized the CD56 homophilic interaction among cancer cells and between immune cells and cancer cells. Finally, by blocking the mitogen-activated protein kinase (MAPK) pathway and the phosphoinositide 3-kinase (PI3K)–Akt pathway, we showed that IL-15 stimulation directly led to CD56 upregulation. In conclusion, these results underscore the previously neglected importance of CD56 expression on immune cells, benefiting current and future immune therapeutic options.

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CD56 (Neural Cell Adhesion Molecule) Expression in Ovarian Carcinomas: Association With High-Grade and Advanced Stage But Not With Neuroendocrine Differentiation

Cited by 19 publications

References 21 publications

The panel of syntaxin 1 and insulinoma‐associated protein 1 outperforms classic neuroendocrine markers in pulmonary neuroendocrine neoplasms

The panel of syntaxin 1 and insulinoma‐associated protein 1 outperforms classic neuroendocrine markers in pulmonary neuroendocrine neoplasms

Well-Differentiated Papillary Mesothelioma with Omental Calcifications: A Case Report and Review of the Literature

CD56 Homodimerization and Participation in Anti-Tumor Immune Effector Cell Functioning: A Role for Interleukin-15

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