CD56 might be a useful diagnostic marker of müllerian-derived tumors: report of an uterine tumor resembling ovarian sex cord tumor (UTROSCT) suggesting polyphenotypic origin and review of the literature

Özer, Hatice; Aker, Handan; Mutlu, Ahmet; Yanık, Ali; Koç, Tülay; Keser, Hande

doi:10.12808/bcs.v2i3.31

Cited by 2 publications

(4 citation statements)

References 21 publications

(50 reference statements)

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“…Studies associated with CD56 and gynecological malignant tumors has not been observed, except a few publications that may be helpful in differentiating ovarian endometriosis from endometrioid tumors and in diagnostic value in endometrial stromal tumors [25,[45][46][47][48][49][50][51]. Working with CD56 in our tumor groups positive staining was detected in OSC (40%), in TSC (37.5%), and in EEC (6.5%), but staining was not detected in ESC, PSC and PMM cases.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Relationship between Malignant Tumors Originated from Peritoneal and Müllerian Epithelium with the Primary and Secondary Müllerian Systems-Immunohistochemical Analysis with Six Markers

Çiftçi¹

2017

Int J Pathol Clin Res

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The origin of ovarian epithelial tumors is still indistinct. Mülle-rian and coelomic hypothesis are controversial. Recently, there is also a small number of reports that tubo-peritoneal junction may play an important role in the development of tubo-ovarian tumors. Therefore, we aimed to investigate the relationship between tumors originating from Mullerian epithelium and peritoneal mesothelium, in other words primary and secondary Müllerian systems.Seventy malignant tumors originating from the Müllerian epithelium and peritoneal mesothelium were included in the study. Tumors were analysed immunohistochemically for PAX8, WT1, CD56, Ber-EP4, ER and desmin expression. We evaluated the study based on three phases. Firstly, we investigated immunohistochemical stainings of different tumor types in different locations. Secondly, we assessed immunohistochemical characteristics according to their histologicals subtypes, and finally their relationship with primary or secondary Müllerian systems.As a result different immunohistochemical features were detected between both localization and histological types of these tumor groups.Absence of immunoreactivity of PAX8, WT1 and CD56 in endometrial serous carcinomas and, the presence of high immunoreactivity in ovarian and tubal serous carcinomas was considered to be an indicator of different origins of these tumors as primary and secondary Müllerian systems. It also seems possible that tubo-peritoneal junction could be the junction between primary and secondary Müllerian systems and, may play an important role in the development of tubo-ovarian tumors.

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Section: Discussionmentioning

confidence: 99%

Investigation of the Relationship between Malignant Tumors Originated from Peritoneal and Müllerian Epithelium with the Primary and Secondary Müllerian Systems-Immunohistochemical Analysis with Six Markers

Çiftçi¹

2017

Int J Pathol Clin Res

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“…The coexistence of UTROSCT with other tumors at the time of surgery was not unusual, mostly with typical leiomyomas [18,27,[41][42][43]45,48,60,103], but also with other neoplasms such as a second UTROSCT [29,60], ovarian sex cord stromal tumors [41], gastrointestinal stromal tumors [94], endometrial adenoacanthoma [17], cervical intraepithelial neoplasia [120], or cervical metastasis from breast cancer [40].…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Other popular antibodies used in the diagnosis of UTROSCT are those immunoreactive for mesenchymal and epithelial elements, including Vimentin, Desmin, Cytokeratin, Epithelial Membrane Antigen (EMA), CD10, and estrogen/progesterone receptors (ER/PR) [5,41]. However, several studies rely on alternative algorithms [42,96,97,100,101,135,136], considering tumors such as UTROSCT to be negative for Calretinin but positive for other sex cord markers. Nogales et al emphasize that UTROSCTs are not "a discrete entity but a group of tumors that do not necessarily have a stereotyped morphology and are only defined by comparison with histologically equivalent ovarian tumors.…”

Section: Gross and Ultrastructural Appearancesmentioning

confidence: 99%

“…Some authors favor CD56 as the most reliable immunohistochemical UTROSCT marker [41,42]. A review on the immunohistochemical features of the 44 cases of UTROSCT reported by Abdullazade et al showed CD56 expression in 100%, followed by positivity for Calretinin in 94%, AE1/AE3 in 73%, CD10 in 50%, Inhibin in 49%, Desmin in 46%, EMA in 29%, and Caldesmon in 7% of cases [41].…”

Section: Gross and Ultrastructural Appearancesmentioning

confidence: 99%

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Uterine Tumors Resembling Ovarian Sex Cord Tumors (UTROSCTs): A Scoping Review of 511 Cases, Including 2 New Cases

Watrowski,

Palumbo,

Guerra

et al. 2024

Medicina

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Uterine Tumors Resembling Ovarian Sex Cord Tumors (UTROSCTs) are rare uterine mesenchymal neoplasms with uncertain biological potential. These tumors, which affect both premenopausal and postmenopausal women, usually have a benign clinical course. Nevertheless, local recurrences and distant metastases have been described. By analyzing 511 cases retrieved from individual reports and cases series, we provide here the most comprehensive overview of UTROSCT cases available in the literature, supplemented by two new cases of UTROSCTs. Case 1 was an asymptomatic 31-year-old woman who underwent a laparoscopic resection of a presumed leiomyoma. Case 2 was a 58-year-old postmenopausal woman with abnormal vaginal bleeding who underwent an outpatient hysteroscopic biopsy of a suspicious endometrial area. In both cases, immunohistochemical positivity for Calretinin and Inhibin was noted, typical for a sex cord differentiation. In both cases, total laparoscopic hysterectomy with bilateral salpingo-oophorectomy was performed. In light of the available literature, no pathognomonic clinical or imaging finding can be attributed to UTROSCT. Patients usually present with abnormal uterine bleeding or pelvic discomfort, but 20% of them are asymptomatic. In most cases, a simple hysterectomy appears to be the appropriate treatment, but for women who wish to become pregnant, uterus-preserving approaches should be discussed after excluding risk factors. Age, tumor size, lymphovascular space invasion, nuclear atypia, and cervical involvement are not reliable prognostic factors in UTROSCT. The current research suggests that aggressive cases (with extrauterine spread or recurrence) can be identified based on a distinct genetic and immunohistochemical phenotype. For instance, UTROSCTs characterized by GREB1::NCOA1-3 fusions and PD-L1 molecule expression appear to be predisposed to more aggressive behaviors and recurrence, with GREB1::NCOA2 being the most common gene fusion in recurrent tumors. Hence, redefining the criteria for UTROSCTs may allow a better selection of women suitable for fertility-sparing treatments or requiring more aggressive treatments in the future.

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CD56 might be a useful diagnostic marker of müllerian-derived tumors: report of an uterine tumor resembling ovarian sex cord tumor (UTROSCT) suggesting polyphenotypic origin and review of the literature

Cited by 2 publications

References 21 publications

Investigation of the Relationship between Malignant Tumors Originated from Peritoneal and Müllerian Epithelium with the Primary and Secondary Müllerian Systems-Immunohistochemical Analysis with Six Markers

Investigation of the Relationship between Malignant Tumors Originated from Peritoneal and Müllerian Epithelium with the Primary and Secondary Müllerian Systems-Immunohistochemical Analysis with Six Markers

Uterine Tumors Resembling Ovarian Sex Cord Tumors (UTROSCTs): A Scoping Review of 511 Cases, Including 2 New Cases

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