CD52/FLAG and CD52/HA Fusion Proteins as Novel Magnetic Cell Selection Markers
Oleg Kandarakov,
Natalia Polyakova,
Alexandra Petrovskaya
et al.
Abstract:At present, magnetic selection of genetically modified cells is mainly performed with surface markers naturally expressed by cells such as LNGFR, CD4 and H-2Kk. The disadvantage of such markers is the possibility of their undesired and poorly predictable expression by unmodified cells before or after cell manipulation, which makes it essential to develop new surface markers that would not have such a drawback. Earlier, modified CD52 surface protein variants with embedded HA and FLAG epitope tags (CD52/FLAG and… Show more
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