CD51 Intracellular Domain Promotes Cancer Cell Neurotropism through Interacting with Transcription Factor NR4A3 in Colorectal Cancer

Huang, Tianze; Lin, Yanyun; Jun-guo, Chen; Hu, Jiancong; Chen, Hao; Zhang, Yanhong; Zhang, Bin; He, Xiaosheng

doi:10.3390/cancers15092623

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…We also observed HPV-associated activation of NR4A3, which was situated 170 kb downstream (3') of an HPV breakpoint that was part of a multi-breakpoint event bridging two chromosomes. NR4A3 is a nuclear receptor and transcription factor with both oncogenic and tumor suppressive roles documented in cancer [33][34][35][36] . It is also a transcriptional target of p53, which is known to be targeted for degradation by E6 in HPV-driven tumors, suggesting its expression would normally be reduced 37,38 .…”

Section: Discussionmentioning

confidence: 99%

Genomic structures and regulation patterns at HPV integration sites in cervical cancer

Porter,

O’Neill,

MacLennan

et al. 2023

Preprint

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Human papillomavirus (HPV) integration has been implicated in transforming HPV infection into cancer, but its genomic consequences have been difficult to study using short-read technologies. To resolve the dysregulation associated with HPV integration, we performed long-read sequencing on 63 cervical cancer genomes. We identified six categories of integration events based on HPV-human genomic structures. Of all HPV integrants, defined as two HPV-human breakpoints bridged by an HPV sequence, 24% contained variable copies of HPV between the breakpoints, a phenomenon we termed heterologous integration. Analysis of DNA methylation within and in proximity to the HPV genome at individual integration events revealed relationships between methylation status of the integrant and its orientation and structure. Dysregulation of the human epigenome and neighboring gene expression inciswith the HPV-integrated allele was observed over megabase-ranges of the genome. By elucidating the structural, epigenetic, and allele-specific impacts of HPV integration, we provide insight into the role of integrated HPV in cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Genomic structures and regulation patterns at HPV integration sites in cervical cancer

Porter,

O’Neill,

MacLennan

et al. 2023

Preprint

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The depth of perineural invasion is an independent prognostic factor for stage II colorectal cancer

Chen,

Wang,

Chen

et al. 2024

BMC Cancer

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Background Perineural invasion (PNI) is the invasion of nerves by cancer cells and is associated with poor survival in stage II colorectal cancer. However, PNI can be further subdivided according to the depth of invasion, and the depth of PNI has not been clearly linked to prognosis. Method This study aimed to assess the prognostic value of different depths of PNI in stage II colorectal cancer. We defined PNI in the submucosal plexus and myenteric plexus as superficial perineural invasion (sup-PNI) and PNI in the subserous plexus as deep perineural invasion (deep-PNI). Patients were divided into three groups based on the depth of PNI: sup-PNI, deep-PNI and non-PNI. Then, univariate and multivariate Cox regression analyses were conducted to evaluate the role of PNI in the prognosis of stage II colorectal cancer. Results This study enrolled 3508 patients with stage II colorectal cancer who underwent resection for primary colorectal lesions between January 2013 and September 2019. Clinicopathological features, including elevated carcinoembryonic antigen (CEA) levels, T4 stage, poor differentiation, deficient DNA mismatch repair (dMMR), and vascular invasion, were correlated with deep-PNI. Multivariate analyses revealed that deep-PNI was associated with worse overall survival (OS; hazard ratio [HR], 3.546; 95% confidence interval [CI], 2.307–5.449; P < 0.001) and disease-free survival (DFS; HR, 2.921; 95% CI, 2.032–4.198; P < 0.001), compared with non-PNI. Conversely, no significant difference in OS or DFS was observed between the sup-PNI and non-PNI groups in multivariate analyses. Conclusions The study demonstrated that the depth of PNI was an independent prognostic factor for patients with stage II colorectal cancer, and patients with deep PNI had a worse prognosis. Thus, patients with PNI require further subdivision according to the depth of invasion.

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CD51 Intracellular Domain Promotes Cancer Cell Neurotropism through Interacting with Transcription Factor NR4A3 in Colorectal Cancer

Cited by 2 publications

References 62 publications

Genomic structures and regulation patterns at HPV integration sites in cervical cancer

Genomic structures and regulation patterns at HPV integration sites in cervical cancer

The depth of perineural invasion is an independent prognostic factor for stage II colorectal cancer

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