CD5+ B lymphoproliferative disorder with subsequent development of plasma cell leukaemia: Diagnostic and aetiologic reasoning

Abstract

This report of PCL development in a patient with residual CD5+ B LPD, emphasizes the need for comprehensive diagnostic evaluation of such cases and scrutiny of their aetiological relationship, including FC immunophenotyping due to its high analytical sensitivity and multiparametric capacity compared to morphology or immunohistochemistry alone. © 2017 International Clinical Cytometry Society.

A rare case of primary plasma cell leukemia exhibiting the small-cell variant of plasma cells

“…McKenney et al [7] Heerema-McKenney et al [7] Gounari et al [8] Loureiro et al [9] Teriaky et al [ Clonal plasma cells in the bone marrow exhibited a CD19 -/CD20 + /CD38 + /CD56 -/CD138 + phenotype and cytoplasmic lambda light-chain restriction gated by CD45and low side scatter.…”

“…To date, only 5 cases of small-cell-type PCL ( Table 1 ) have been reported, while clonal PCs of the small-cell-type are found only in 3.4% of PCM [ 7 - 10 ]. The median age of the 6 cases including ours was 70.2 years with no demographic preponderance.…”