CD5+and CD5−B1-like Lymphocytes in Healthy Guinea Pig

Wicher, Victoria; Dilwith, Robert L.; Bürger, Reinhard; Wicher, Konrad

doi:10.1006/clin.1997.4425

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…The percentage of B cells expressing CD5 in the adult horse peripheral blood varies by species: 10–20% in humans (Carsetti et al, 2004 and Dalloul, 2009), 10–20% in the pig (Appleyard and Wilkie, 1998 and Wilson and Wilkie, 2007), 1% in the guinea pig (Dilwith and Wicher, 1997), and 5–35% in cattle (Naessens and Williams, 1992). In contrast, the majority of B cells in the rabbit are CD5 + (Raman and Knight, 1992), while no CD5 is expressed in rat B cells (Vermeer et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Taken the fact that natural killer cells do not express CD5 (Dalloul, 2009), the unaccounted for CD2 + CD5 + CD3 − population would possibly represent a subset of B cells. CD5 + B cells have been observed in different species, including pigs (Appleyard and Wilkie, 1998), cattle (Naessens and Williams, 1992), rabbits (Raman and Knight, 1992), and guinea pigs (Dilwith and Wicher, 1997). …”

Section: Introductionmentioning

confidence: 99%

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Developmental expression of B cell molecules in equine lymphoid tissues

Prieto

Tallmadge

Felippe

2017

Veterinary Immunology and Immunopathology

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Identification and classification of B cell subpopulations has been shown to be challenging and inconsistent among different species. Our study tested aspects of ontogeny, phenotype, tissue distribution, and function of equine CD5hi B cells, which represented a greater proportion of B cells early in development and in the peritoneal cavity. CD5hi and CD5lo B cells differentially expressed B cell markers (CD2, CD21, IgM) measured using flow cytometry, but similar mRNA expression of signature genes (DGKA, FGL2, PAX5, IGHM, IL10) measured using quantitative RT-PCR. Sequencing lambda light chain segments revealed that CD5hi B cells generated diverse immunoglobulin repertoires, and more frequently bound to fluorescence-labeled phosphorylcholine. This study shows developmental characteristics and tissue distribution of a newly described subpopulation of B cells in the horse.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Developmental expression of B cell molecules in equine lymphoid tissues

Prieto

Tallmadge

Felippe

2017

Veterinary Immunology and Immunopathology

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“…Functionally, elevation of rainbow trout (Oncorhynchus mykiss Walbaum) natural Ig has been correlated with a concurrent increase in resistance to bacterial infection [17] and natural rainbow trout anti-TNP antibodies protect virus targeted cells from infection [18]. Here, snapper (Pagrus auratus) were assessed for natural IgM that binds protease treated erythrocytes, a model assay system that has been used extensively to detect natural IgM in humans [10], mice [5,19], rats [20], rabbits [20] and guinea pigs [21]. The data suggest that normal snapper serum may contain IgM that binds BrSRBC, activating the classical complement pathway.…”

Section: Introductionmentioning

confidence: 99%