CD4CD8αα Lymphocytes, A Novel Human Regulatory T Cell Subset Induced by Colonic Bacteria and Deficient in Patients with Inflammatory Bowel Disease

Sarrabayrouse, Guillaume; Bossard, Céline; Chauvin, Joë-Marc; Jarry, Anne; Meurette, G.; Quévrain, Elodie; Bridonneau, Chantal; Preisser, Laurence; Asehnoune, Karim; Labarrière, Nathalie; Altare, Frédéric; Sokol, Harry; Jotereau, Francine

doi:10.1371/journal.pbio.1001833

Cited by 114 publications

(112 citation statements)

References 40 publications

(74 reference statements)

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“…38,39 This may be partly explained by the important role of gut bacteria in the induction of colonic regulatory T cells (T regs ). 40,41 A recent elegantly designed murine study reported that the reduction in the microbiota-derived short-chain fatty acids, specifically the histone deacetylase inhibitor (HDACi) butyrate, in intestinal epithelial cells was associated with GVHD. 42 In this study, restoration of butyrate improved intestinal epithelial junctional integrity, decreased apoptosis, decreased clinical GVHD scores and improved survival.…”

Section: Recovery Of Mucosal Injurymentioning

confidence: 99%

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

2016

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Infection is the leading cause of non-relapse mortality after allogeneic haematopoietic cell transplantation (HCT). This occurs as a result of dysfunction to the host immune system from the preparative regimen used prior to HCT, combined with a delay in reconstitution of the donorderived immune system after HCT. In this article, we elaborate on the process of immune reconstitution post-HCT that begins with the innate system and is followed by recovery of adaptive immunity. Simultaneously, we describe how the tempo of immune reconstitution influences the risk of various infections. We explain some of the key differences in immune reconstitution and the consequent risk of infections in recipients of peripheral blood stem cell, bone marrow or umbilical cord blood grafts. Other factors that impact on immune recovery are also highlighted. Finally, we allude to various strategies that are being tested to enhance immune reconstitution post-HCT.

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Section: Recovery Of Mucosal Injurymentioning

confidence: 99%

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

2016

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“…Interestingly the Metastats defined the genus Clostridium_IV more abundant in the Landrace. The genus Clostridium_IV was previously reported to play a key role in systemic immunity (Sarrabayrouse et al, 2014). The less opportunistic pathogens identified in the Landrace could be due to the existence of the prevalent Clostridium species, however further studies are needed to confirm this.…”

Section: Genus Level Differential Abundance Testmentioning

confidence: 92%

Comparison Analysis of Swine Gut Microbiota between Landrace and Yorkshire at Various Growth Stages

Unno¹

2014

The Korean Journal of Microbiology

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In this study, we conducted a next generation sequencing based microbial community analysis to investigate gut microbiota of the two commercially most available swine breeds, Yorkshire and Landrace. Bacterial 16S rRNA gene was amplified from fecal DNA using universal primer sets designed for V4 regions. Our comparison analysis of the gut microbiota of the two breeds suggested that their gut microbiota changed depending on the growth stages, while the difference between the two breeds was insignificant. However, there was a limited number of genera, the abundance of which was found to be different between the breeds. Those included the genus Xylanibacter in the Yorkshire samples, which was previously reported as a fiber digesting bacteria, likely increasing energy harvesting capacity of swine. In addition, others included opportunistic pathogens mostly found in the Yorkshire samples while the Landrace samples had significantly more prevalent Clostridium_IV species that were known to play a key role in systemic immunity of hosts. While microbial community shifts was found to be associated with growth stages, the difference between the two breeds seemed to be insignificant. However, there were several bacterial genera showing differential abundance, which may affect growth of hosts.

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“…Moreover, it is able to stimulate a recently identified human regulatory T cell subset (CD4CD8αα) [61]. These data pave the way to use anti-inflammatory commensals or their active metabolites as treatment for IBD.…”

Section: New Generation Of Probiotic Strains or Combinationsmentioning

confidence: 99%

Targeting the Microbiome in Inflammatory Bowel Disease: Critical Evaluation of Current Concepts and Moving to New Horizons

Bejaoui

Sokol

Marteau

2015

Dig Dis

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Microorganisms present in the intestine possess proinflammatory or anti-inflammatory activities which may modulate inflammatory bowel disease (IBD). The concepts followed by researchers in trying to target the microbiota in IBD were to decrease pathogens or pathobionts, or only the microbial load, and more recently, to favor growth and persistence of favorable microorganisms. We review, here, those concepts and critically analyze the clinical data (especially randomized controlled trials) obtained using antibiotics and probiotics. We eventually present and criticize the rational and data obtained so far following new research strategies including the use of new probiotics, genetically modified organisms and fecal transplantation.

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CD4CD8αα Lymphocytes, A Novel Human Regulatory T Cell Subset Induced by Colonic Bacteria and Deficient in Patients with Inflammatory Bowel Disease

Abstract: Gut bacterium Faecalibacterium prausnitzii activates a newly identified set of human IL-10-producing Treg cells (CD4CD8αα lymphocytes), revealing a mechanism by which commensal microbes contribute to host immunity.

Cited by 114 publications

References 40 publications

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

Comparison Analysis of Swine Gut Microbiota between Landrace and Yorkshire at Various Growth Stages

Targeting the Microbiome in Inflammatory Bowel Disease: Critical Evaluation of Current Concepts and Moving to New Horizons

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