CD47 overexpression is related to tumour‐associated macrophage infiltration and diffuse large B‐cell lymphoma progression

Abstract

CD47 overexpression is related to tumour-associated macrophage infiltration and diffuse large B-cell lymphoma progressionDear Editor, Cluster of differentiation 47 (CD47) belongs to the immunoglobulin superfamily and is considered an adverse prognostic risk factor for diffuse large B-cell lymphoma (DLBCL) patients. 1 Accumulating evidence reveals that F I G U R E 1 Clinical outcomes according to CD47 expression in diffuse large B-cell lymphoma (DLBCL) patients with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen. (A and B) Kaplan-Meier curves of progression-free survival (PFS) and overall survival (OS) according to CD47 mRNA expression in DLBCL patients treated with R-CHOP regimen. Data are analysed by log-rank test. (C and D) Univariate analysis of predictors for PFS and OS. Hazard ratios (HR), 95% confidence intervals (95% CIs) and p-values are indicated on the right of each forest plot.