CD46 processing: A means of expression

Abstract

CD46 is a ubiquitously expressed type I transmembrane protein, first identified as a regulator of complement activation, and later as an entry receptor for a variety of pathogens. The last decade has also revealed the role of CD46 in regulating the adaptive immune response, acting as an additional costimulatory molecule for human T cells and inducing their differentiation into Tr1 cells, a subset of regulatory T cells. Interestingly, CD46 regulatory pathways are defective in T cells from patients with multiple sclerosis, asthma and rheumatoid arthritis, illustrating its importance in regulating T cell homeostasis. Indeed, CD46 expression at the cell surface is tightly regulated in many different cell types, highlighting its importance in several biological processes. Notably, CD46 is the target of enzymatic processing, being cleaved by metalloproteinases and by the presenilin/gamma secretase. This processing is required for its functions, at least in T cells. This review will summarize the latest updates on the regulation of CD46 expression and on its effects on T cell activation.

Wavelet feature extraction and genetic algorithm for biomarker detection in colorectal cancer data

“…Within next 2-3 years, the investigators are "planning to trial a new vaccine for colorectal cancer in patients with an intact immune system (60% of patients with colorectal cancer)". The detection of CD46 supports their conclusions based on recent research that CD46 is involving in the immune response [47,48,49,50,51,52].…”

Nipah Virus Envelope-Pseudotyped Lentiviruses Efficiently Target ephrinB2-Positive Stem Cell Populations In Vitro and Bypass the Liver Sink When Administered In Vivo

“…For the henipaviruses, a large body of work has accumulated regarding the independent determinants of fusogenicity in F and G. Thus, F can be made even more fusogenic by incorporating other mutations that are already well characterized in the literature (3,27,28,(74)(75)(76). Indeed, even the specificity and fusogenicity of G itself can be optimized based on published structural and functional data (5,12,40,41,53,54,77). Altogether, this confluence of properties makes NiVpp highly attractive for further development as targeted gene therapy vectors for in vitro and in vivo applications.…”

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Emerging roles of the γ-secretase-notch axis in inflammation

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