CD44 variant 6 is associated with prostate cancer metastasis and chemo‐/radioresistance

Abstract

Our findings demonstrate that CD44v6 is an important cancer stem cell-like marker associated with CaP proliferation, invasion, adhesion, metastasis, chemo-/radioresistance, and the induction of EMT as well as the activation PI3K/Akt/mTOR and Wnt signaling pathways, suggesting that CD44v6 is a novel therapeutic target to sensitize CaP cells to chemo/radiotherapy.

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

“…Furthermore, irradiated aMSCs retained their phenotype over time after IR, which was mainly evident by the constant expression of surface antigens Sca1, CD29, CD44 and CD105; which are cell surface antigens that have been linked with the resistance to IR in previous studies [92][93][94].…”

“…Another characteristic of MSCs that has been useful is their radiation resistance, which allows these cells to be a reliable candidate in RORM therapies, especially during and/or before RT [93,95,104]. Such studies have been conducted on bmMSCs only.…”

“…have been linked with cellular radio-resistance [92,93]. In addition, the surface antigen CD105 presence is important for normal cellular DNA repair [94].…”

The role of adhesion molecules in acute myeloid leukemia and (hemato)oncology: A systematic review

“…Variant 6 isoform of CD44 is a cancer stem cell-like marker in prostate cancer, associated with proliferation, invasiveness, metastasis and chemo-/ radioresistance. These effects are mediated through PI3K activation and the Wnt signalling pathway 142 . Variant isoforms of CD44 are also relevant to the progression of head and neck squamous cell carcinoma 143 .…”

Molecularly targeted radiosensitization chances towards gene aberration-due organ confined/regionally advanced prostate cancer radioresistance

“…Besides the outlined conditions (Table 1), it has to be taken into consideration some PCa cell radioresistance biomarkers, among which particularly EMT (epithelial-mesenchymal transition with down-expression of E-cadherin compared with mesenchyme-peculiar expression of vimentin) and CD44-variant 6 marker, whose small interfering RNA (siRNA)-mediated knock-down can suppress, by deactivation of PI3K-Akt/mTOR and Wnt/βcatenin signaling pathways, the PCa cells growth, © C I C E d i z i o n i I n t e r n a z i o n a l i so increasing their radio-and chemosensitivity (11,12).…”