CD44 Receptor–Specific and Redox-Sensitive Nanophotosensitizers of Hyaluronic Acid–Chlorin e6 Tetramer Having Diselenide Linkages for Photodynamic Treatment of Cancer Cells

Ciprofloxacin-Releasing ROS-Sensitive Nanoparticles Composed of Poly(Ethylene Glycol)/Poly(D,L-lactide-co-glycolide) for Antibacterial Treatment

“…These results indicate that LGseseTAPEG nanoparticles effectively respond to the oxidative stress and then their physical properties can be changed according to the intensity and duration of the oxidative stress. Kim et al, also reported that polymeric conjugates having diselenide linkages underwent ROS-sensitive changes in morphology, particle size and drug release behavior [ 27 ]. Like their nanoparticles, our nanoparticles also display ROS-sensitive changes of morphology, particle size distribution and drug release behavior.…”

“…In this study, we fabricated CIP-encapsulated nanoparticles using a star-shaped copolymer composed of methoxy poly(ethylene glycol) (mPEG) and poly(D,L-lacide-co-glycolide) (PLGA) having a diselenide linkage and a tetraacid (abbreviated as LGseseTAPEG). Since diselenide linkages can be cleaved under oxidative stress, these nanoparticles can be used to deliver CIP in a ROS-specific manner against UTI [ 27 ]. We studied ROS-sensitivity and ROS-sensitive drug release of LGseseTAPEG nanoparticles, and their antibacterial activity.…”

Caffeic Acid Phenethyl Ester-Incorporated Radio-Sensitive Nanoparticles of Phenylboronic Acid Pinacol Ester-Conjugated Hyaluronic Acid for Application in Radioprotection

“…Since CAPE itself is a lipophilic agent and is hardly dissolved in an aqueous solution, nanoparticles can solve these problems, i.e., nanoparticles enable us to dissolve CAPE in an aqueous solution [28]. Furthermore, nanoparticles can be modified to be sensitive to physicochemical stimulus such as radiation, pH, ROS, magnetic field, and light [32][33][34][35][36][37]. HAsPBPE nanoparticles can respond to ROS since the PBPE moiety and thiol group in TbEA in the polymer backbone are known to have ROS-sensitivity and these moieties are able to be decomposed in the oxidative stress [45].…”

“…Nano-dimensional vehicles such as nanoparticles, polymeric micelles, liposomes or colloidal carriers have been extensively investigated in the diverse field of biomedical science [28][29][30][31][32]. Especially, nanoparticles have been frequently considered for stimulisensitive drug delivery of bioactive agents, i.e., they can be modified to respond against the stimulus in the biological system such as acidic pH, temperature, magnetic field, oxidative stress, light, and irradiation [32][33][34][35][36][37]. For example, Choi et al reported that iron oxide-incorporated lipocomplexes respond to the magnetic field, concentrate around the tumor mass, and then specifically target cancer [32].…”

“…For example, Choi et al reported that iron oxide-incorporated lipocomplexes respond to the magnetic field, concentrate around the tumor mass, and then specifically target cancer [32]. Polymer conjugates having diselenide linkage can be used to target cancer cells and deliver the cancer drug through reactive oxygen species (ROS)-sensitive cleavage of selenide linkage since the tumor microenvironment normally revealed increased redox potential and elevated ROS level [35]. Choi et al reported that methoxy poly(ethylene glycol)-b-poly(DL-lactide-co-glycolide) block copolymer nanoparticles having diselenide linkages responded to irradiation and then specifically released ebselen, i.e., they showed that the ebselen release rate was accelerated according to the dose of irradiation [37].…”