CD44 expression is related to poor prognosis of hypopharyngeal squamous cell carcinoma

Uwa, Nobuhiro; Kataoka, Tatsuki R.; Torii, Ikuko; Sato, Ayuko; Nishigami, Takashi; Song, Misa; Daimon, Takashi; Saeki, Nobuo; Sagawa, Kousuke; Mouri, Takeshi; Terada, Tomonori; Sakagami, Masafumi; Tsujimura, Tohru

doi:10.3109/00016489.2010.528792

Cited by 14 publications

(13 citation statements)

References 17 publications

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“…Although some studies in human H&N and other malignancies have shown that CD44 can be prognostic for treatment outcome, we did not find a significant correlation between CD44 levels and either ST or PFI in feline oral SCC . One plausible explanation for this discrepancy could be the varied assortment of CD44 isoforms.…”

Section: Discussioncontrasting

confidence: 99%

“…In human H&N SCC, cancer cells positive for the cell surface marker CD44 (a hyaluronic acid receptor), have been shown to be more tumourigenic than cancer cells negative for CD44 . Other studies revealed that human H&N SCC patients with greater numbers of CD44 positive cancer cells present with more advanced clinical tumour stages and significantly lower survival rates, as well as higher rates of tumour recurrence and tumour implantation in immunocompromised mice . The original study advocating CD44 as a TIC marker, also showed that CD44 positive cancer cells – but not CD44 negative cancer cells – differentially expressed Bmi‐1 at both the RNA and protein levels .…”

Section: Introductionmentioning

confidence: 99%

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Predicting clinical outcome in feline oral squamous cell carcinoma: tumour initiating cells, telomeres and telomerase

Yoshikawa

Maranon

Battaglia

et al. 2014

Vet Comparative Oncology

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Feline oral squamous cell carcinoma (SCC) has very poor prognosis. Here, a retrospective pilot study was conducted on 20 feline oral SCC patients who underwent stereotactic radiation therapy (SRT), to evaluate: (1) the value of putative tumour initiating cell (TIC) markers of human head and neck SCC (CD44, Bmi-1); (2) telomere length (TL) specifically in putative TICs; and (3) tumour relative telomerase activity (TA). Significant inverse correlations were found between treatment outcomes and Bmi-1 expression, supporting the predictive value of Bmi-1 as a negative prognostic indicator. While TL exhibited a wide range of variability, particularly in very short fractions, many tumours possessed high levels of TA, which correlated with high levels of Bmi-1, Ki67 and EGFR. Taken together, our results imply that Bmi-1 and telomerase may represent novel therapeutic targets in feline oral SCC, as their inhibition - in combination with SRT - would be expected to have beneficial treatment outcome.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predicting clinical outcome in feline oral squamous cell carcinoma: tumour initiating cells, telomeres and telomerase

Yoshikawa

Maranon

Battaglia

et al. 2014

Vet Comparative Oncology

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“…In contrast to absent/weak CD44 intensity staining, medium/high CD44 intensity staining correlated to worse prognosis for OSCC in general and for HPV DNA + OSCC. These results are in line with previous reports in HNSCC and other malignancies . Furthermore, it was proposed that CD44 characterize cancer stem cells in HNSCC .…”

Section: Discussionsupporting

confidence: 93%

Absent/weak CD44 intensity and positive human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma indicates a very high survival

et al. 2013

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Patients with human papillomavirus DNA positive (HPVDNA+) oropharyngeal squamous cell carcinoma (OSCC) have better clinical outcome than those with HPV DNA negative (HPVDNA−) OSCC upon intensive oncological treatment. All HPVDNA+ OSCC patients may not require intensive treatment, however, but before potentially deintensifying treatment, additional predictive markers are needed. Here, we examined HPV, p16INK4a, and CD44 in OSCC in correlation to clinical outcome. Pretreatment tumors from 290 OSCC patients, the majority not receiving chemotherapy, were analyzed for HPV DNA by Luminex and for p16INK4a and CD44 by immunohistochemistry. 225/290 (78%) tumors were HPVDNA+ and 211/290 (73%) overexpressed p16INK4a, which correlated to presence of HPV (P < 0.0001). Presence of HPV DNA, absent/weak CD44 intensity staining correlated to favorable 3-year disease-free survival (DFS) and overall survival (OS) by univariate and multivariate analysis, and likewise for p16INK4a by univariate analysis. Upon stratification for HPV, HPVDNA+ OSCC with absent/weak CD44 intensity presented the significantly best 3-year DFS and OS, with >95% 3-year DFS and OS. Furthermore, in HPVDNA+ OSCC, p16INK4a+ overexpression correlated to a favorable 3-year OS. In conclusion, patients with HPVDNA+ and absent/weak CD44 intensity OSCC presented the best survival and this marker combination could possibly be used for selecting patients for tailored deintensified treatment in prospective clinical trials.Absence of/weak CD44 or presence of human papillomavirus (HPV) DNA was shown as a favorable prognostic factors in tonsillar and tongue base cancer. Moreover, patients with the combination of absence of/weak CD44 and presence of HPV DNA presented a very favorable outcome. Therefore, we suggest that this marker combination could potentially be used to single out patients with a high survival that could benefit from a de-escalated oncological treatment.

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“…CD44 is a cell-surface glycoprotein involved in cell-cell interactions, cell migration, and adhesion with multiple isoforms (splice variants) known to be associated with cell transformation and tumor dissemination [103–106]; Clinically, overexpression of CD44 was associated with poor prognoses and decreased 5-year survival in HNSCC patients [107–110], although its clinical relevance seems dependent on the anatomical site where the cancer originates [106, 111–114]. The aldehyde dehydrogenase (ALDH) family of cytosolic enzymes catalyses the oxidation of aliphatic and aromatic aldehydes to carboxylic acids and ALDH1 is a family member that has a role in the conversion of retinol to retinoic acid, which is important for proliferation, differentiation and survival.…”

Section: Clinical Relevance Of Cancer Stem Cells In Oral Tumorigenesismentioning

confidence: 99%

Oral epithelial stem cells—Implications in normal development and cancer metastasis

Papagerakis

Pannone

Zheng

et al. 2014

Experimental Cell Research

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Oral mucosa is continuously exposed to environmental forces and has to be constantly renewed. Accordingly, the oral mucosa epithelium contains a large reservoir of epithelial stem cells necessary for tissue homeostasis. Despite considerable scientific advances in stem cell behavior in a number of tissues, fewer studies have been devoted to the stem cells in the oral epithelium. Most of oral mucosa stem cells studies are focused on identifying cancer stem cells (CSC) in oral squamous cell carcinomas (OSCCs) among other head and neck cancers. OSCCs are the most prevalent epithelial tumors of the head and neck region, marked by their aggressiveness and invasiveness. Due to their highly tumorigenic properties, it has been suggested that CSC may be the critical population of cancer cells in the development of OSCC metastasis. This review presents a brief overview of epithelium stem cells with implications in oral health, and the clinical implications of the CSC concept in OSCC metastatic dissemination.

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CD44 expression is related to poor prognosis of hypopharyngeal squamous cell carcinoma

Cited by 14 publications

References 17 publications

Predicting clinical outcome in feline oral squamous cell carcinoma: tumour initiating cells, telomeres and telomerase

Predicting clinical outcome in feline oral squamous cell carcinoma: tumour initiating cells, telomeres and telomerase

Absent/weak CD44 intensity and positive human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma indicates a very high survival

Oral epithelial stem cells—Implications in normal development and cancer metastasis

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