CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines

Roszkowska, Matylda; Skupien, Anna; Wójtowicz, T.; Konopka, Anna; Gorlewicz, Adam; Kisiel, Magdalena; Bekisz, Marek; Ruszczycki, Błażej; Dolezyczek, Hubert; Rejmak, Emilia; Knapska, Ewelina; Mozrzymas, Jerzy W.; Włodarczyk, Jakub; Wilczyński, Grzegorz M.; Dzwonek, Joanna

doi:10.1091/mbc.e16-06-0423

Cited by 60 publications

(64 citation statements)

References 74 publications

(54 reference statements)

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“…In another study, CD44 has been implicated in regulating synaptic plasticity through a mechanism involving regulation of the actin cytoskeleton (48), and altered synaptic plasticity in CD44-null mice may lead to a number of behavioral phenotypes including increased susceptibility to stress-induced anxiety (49). In addition, mice lacking Has3 demonstrate extensive loss of HA in the hippocampus that causes increased cell packing in the CA1 stratum pyramidale (50).…”

Section: Discussionmentioning

confidence: 99%

CD44 Transmembrane Receptor and Hyaluronan Regulate Adult Hippocampal Neural Stem Cell Quiescence and Differentiation

Foster

Xing

et al. 2017

Journal of Biological Chemistry

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Adult neurogenesis in the hippocampal subgranular zone (SGZ) is involved in learning and memory throughout life but declines with aging. Mice lacking the CD44 transmembrane receptor for the glycosaminoglycan hyaluronan (HA) demonstrate a number of neurological disturbances including hippocampal memory deficits, implicating CD44 in the processes underlying hippocampal memory encoding, storage, or retrieval. Here, we found that HA and CD44 play important roles in regulating adult neurogenesis, and we provide evidence that HA contributes to age-related reductions in neural stem cell (NSC) expansion and differentiation in the hippocampus. CD44-expressing NSCs isolated from the mouse SGZ are self-renewing and capable of differentiating into neurons, astrocytes, and oligodendrocytes. Mice lacking CD44 demonstrate increases in NSC proliferation in the SGZ. This increased proliferation is also observed in NSCs grown , suggesting that CD44 functions to regulate NSC proliferation in a cell-autonomous manner. HA is synthesized by NSCs and increases in the SGZ with aging. Treating wild type but not CD44-null NSCs with HA inhibits NSC proliferation. HA digestion in wild type NSC cultures or in the SGZ induces increased NSC proliferation, and CD44-null as well as HA-disrupted wild type NSCs demonstrate delayed neuronal differentiation. HA therefore signals through CD44 to regulate NSC quiescence and differentiation, and HA accumulation in the SGZ may contribute to reductions in neurogenesis that are linked to age-related decline in spatial memory.

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Section: Discussionmentioning

confidence: 99%

CD44 Transmembrane Receptor and Hyaluronan Regulate Adult Hippocampal Neural Stem Cell Quiescence and Differentiation

Foster

Xing

et al. 2017

Journal of Biological Chemistry

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“…In contrast, the N 165 IYF 168 motif is involved in multiple TSPAN5 interactions. TSPAN5-ADAM-10 interaction regulates the intracellular trafficking of the protease and the cleavage of specific targets (Dornier et al, 2012;Haining et al, 2012;Noy et al, 2016;Saint-Pol et al, 2017), such as Notch and CD44 (Jouannet et al, 2016), transmembrane proteins implicated in dendritic spine plasticity (Bijata et al, 2017;Roszkowska et al, 2016). NLG1 also undergoes activity-dependent proteolytic cleavage by ADAM-10 in neurons (Suzuki et al, 2012).…”

Section: Tspan5 Tems Regulates Nlg1 Clusteringmentioning

confidence: 99%

TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering

et al. 2019

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Graphical AbstractHighlights d TSPAN5 is expressed in pyramidal neurons and localizes mainly to dendritic spines d TSPAN5 interacts with neuroligin-1 and promotes its clustering d TSPAN5-neuroligin-1 complex is fundamental for dendritic spine maturation AUTHOR CONTRIBUTIONS Conceptualization, E.M. and M.P.; Methodology, I.C. and M.S.; Investigation, E.M., A.L., L.M., I.C., A.S., J.Z., and E.H.; Writing -Original Draft, E.M. and M.P.; Writing -Review & Editing, E.M., A.L., M.P., V.B., D.C., G.S., and O.T.; Visualization, E.M. and A.L.; Funding Acquisition, D.C., O.T., G.S., and M.P. DECLARATION OF INTERESTSThe authors declare no competing interests.

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“…CD44 antigen is cell surface glycoprotein that is traditionally considered to promote cell‐cell interactions and cell migration and adhesion (Puré & Cuff, ). Recent evidence suggests that this role extends to maintenance of the structural and functional plasticity of dendritic spines (Roszkowska et al, ). The robust change in abundance of CD44 antigen, which was significantly elevated in Group 2 (KA) animals compared to drug treatment groups (Group 3, VEH + PSD; Group 5, VEH + 1400W), suggests either the involvement of the innate immune response (mediated by T‐cell migration) or an ongoing synaptic re‐organization in the aftermath of KA‐induced SE, both of which are plausible.…”

Section: Discussionmentioning

confidence: 99%

The impact of postsynaptic density 95 blocking peptide (Tat‐NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate‐induced epileptogenesis

Tse

Hammond

Simpson

et al. 2019

J of Neuroscience Research

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Antiepileptogenic agents that prevent the development of epilepsy following a brain insult remain the holy grail of epilepsy therapeutics. We have employed a label-free proteomic approach that allows quantification of large numbers of brain-expressed proteins in a single analysis in the mouse (male C57BL/6J) kainate (KA) model of epileptogenesis. In addition, we have incorporated two putative antiepileptogenic drugs, postsynaptic density protein-95 blocking peptide (PSD95BP or Tat-NR2B9c) and a highly selective inducible nitric oxide synthase inhibitor, 1400W, to give an insight into how such agents might ameliorate epileptogenesis. The test drugs were administered after the induction of status epilepticus (SE) and the animals were euthanized at 7 days, their hippocampi removed, and subjected to LC-MS/MS analysis. A total of | 1379 TSE ET al.

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CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines

Cited by 60 publications

References 74 publications

CD44 Transmembrane Receptor and Hyaluronan Regulate Adult Hippocampal Neural Stem Cell Quiescence and Differentiation

CD44 Transmembrane Receptor and Hyaluronan Regulate Adult Hippocampal Neural Stem Cell Quiescence and Differentiation

TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering

The impact of postsynaptic density 95 blocking peptide (Tat‐NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate‐induced epileptogenesis

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