CD4 T-Lymphocytes Count in HIV-&amp;lt;i&amp;gt;Toxoplasma gondii&amp;lt;/i&amp;gt; Co-Infected Pregnant Women Undergoing a Prevention of Mother-to-Child Transmission Program

Katawa, Gnatoulma; Kolou, M; Nadjir, Liza Koboyo; Ataba, Essoham; Bomboma, Gatigbene; Karou, Simplice Damintoti

doi:10.4236/jbm.2018.64006

Cited by 2 publications

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“…Consequently, toxoplasmosis among people living with HIV/AIDS mainly manifests as toxoplasma encephalitis 5 . In pregnant women, toxoplasmosis has been implicated in prenatal and congenital transmission, causing miscarriage or congenitally acquired disorders that primarily affect the central nervous system of neonates 6 . Nigeria has one of the highest HIV prevalences, with 1.4% among adults aged 15–49 years in 2019.…”

Section: Introductionmentioning

confidence: 99%

Serological survey and risk factors associated with Toxoplasma gondii infection among HIV-infected pregnant women attending Abuja Tertiary Hospital, Nigeria

et al. 2020

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Background Toxoplasmosis in pregnancy could induce miscarriage, congenital anomalies in foetuses and encephalitis in HIV-infected people. Hence, there is a need to determine the prevalence of toxoplasmosis in HIV-infected pregnant women to inform clinicians about the significance of maternal toxoplasmosis in antenatal care.AimThis study aimed to determine the seroprevalence of Toxoplasma gondii infection, associated CD4+ T-cell profile and sociodemographic risk factors among pregnant women with or without HIV infection attending the University of Abuja Teaching Hospital, Abuja, Nigeria. MethodsThis hospital-based cross-sectional study involved blood samples collected from 160 HIV-infected and 160 HIV-seronegative pregnant women. These samples were analysed for anti-T. gondii (IgG and IgM) and CD4+ T-cell count using ELISA and flow cytometry, respectively. Sociodemographic variables of participants were collected using structured questionnaires. ResultsThe overall seroprevalence of anti-T. gondii IgG and IgM was 28.8% and 3.8%, respectively. The seroprevalence of anti-T. gondii IgG and IgM was 29.4% and 4.4%, respectively, among HIV-seropositive pregnant women and 28.1% and 3.1%, respectively, among HIV-seronegative women. There was no significant association between the seroprevalence of anti-T. gondii-IgG and anti-T. gondii-IgM with age, gestational age, education level, parity or place of residence of HIV-infected pregnant women (P > 0.05). However, there was significant association between the seroprevalence of anti-T. gondii-IgG (P = 0.03) and anti-T. gondii-IgM (P = 0.01) with education level. CD4+ T-cell count varied significantly between HIV-infected and HIV-uninfected pregnant women (P = 0.035). Conclusion In this study, the seroprevalence of anti-T. gondii IgG and IgM did not differ in HIV-seropositive or HIV-seronegative pregnant women. However, women with primary T. gondii and HIV coinfection had lower CD4+ T-cell count than those with toxoplasmosis monoinfection.

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Section: Introductionmentioning

confidence: 99%

Serological survey and risk factors associated with Toxoplasma gondii infection among HIV-infected pregnant women attending Abuja Tertiary Hospital, Nigeria

et al. 2020

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“…Humanity has been struggling against pathogens. Theses pathogens cause parasitic diseases [1] , bacterial infections and viral such us HIV [2] , hepatitis B [3,4] and recent Covid-19 causes by SARS-CoV-2 [5] . Coronaviridae are single-stranded, positive-sense RNA viruses enveloped non-segmented, designated after their corona or crown-like on electron microscopy [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Human Coronaviruses: Genetics, Virulence Factors and Pathophysiology, Diseases’ Epidemiology

Katawa

Gambogou

Nguepou

et al. 2021

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Coronaviruses are pathogens for both animals and humans. The recent Coronavirus Disease (Covid-19), caused by a novel Coronavirus (SARS-CoV-2), outbreak that took place in Hubei (Wuhan, China) from December 2019 aroused numerous questions regarding the nature and the origin of the SARS-CoV-2. Literature review of the main publications from scientific data bases was undertaken. These data revealed similarities of symptoms and identity of genome with the SARS-CoV. In this review, the genetics and virulence factors of coronaviruses, the disease pathophysiology and epidemiology were examined.

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CD4 T-Lymphocytes Count in HIV-<i>Toxoplasma gondii</i> Co-Infected Pregnant Women Undergoing a Prevention of Mother-to-Child Transmission Program

Abstract: Toxoplasma gondii (T. gondii) is a parasite responsible of toxoplasmosis, a disease often asymptomatic but with serious consequences in pregnant women and immunocompromised subjects. Objective: This study aimed to investigate the impact of T. gondii infection on

Cited by 2 publications

References 14 publications

Serological survey and risk factors associated with Toxoplasma gondii infection among HIV-infected pregnant women attending Abuja Tertiary Hospital, Nigeria

Serological survey and risk factors associated with Toxoplasma gondii infection among HIV-infected pregnant women attending Abuja Tertiary Hospital, Nigeria

Human Coronaviruses: Genetics, Virulence Factors and Pathophysiology, Diseases’ Epidemiology

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