CD4+but not CD8+T cells are required for protection against severe guinea pig cytomegalovirus infections
Tyler B. Rollman,
Zachary W. Berkebile,
Dustin M. Hicks
et al.
Abstract:Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus and the leading cause of infectious disease related birth defects worldwide. How the immune response modulates the risk of intrauterine transmission of HCMV after maternal infection remains poorly understood. Maternal T cells likely play a critical role in preventing infection at the maternal-fetal interface and limiting spread across the placenta, but concerns exist that immune responses to infection may also cause placental dysfunction and adverse preg… Show more
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