CD4+CD45RA−FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes

Haseda, Fumitaka; Imagawa, Akihisa; Murase-Mishiba, Yuko; Terasaki, Jungo; Hanafusa, Toshiaki

doi:10.1111/cei.12116

Cited by 85 publications

(71 citation statements)

References 36 publications

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“…While the majority of studies have reported no differences in the frequency of T regs in peripheral blood isolated from T1D patients, defects in T reg phenotype and suppressive capacity have been reported (20-24). Unfortunately, the majority of data obtained from T1D patients is from peripheral blood, due to the feasibility of obtaining pancreas samples from T1D patients.…”

Section: Loss Of Treg Phenotype and Function In T1d And Autoimmune DImentioning

confidence: 96%

Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?

Visperas

Vignali

2016

The Journal of Immunology

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Regulatory T cells (Tregs) are critical regulators of peripheral immune tolerance. Treg insufficiency can lead to autoimmune disorders, including Type 1 Diabetes (T1D). Increasing evidence in mouse models of T1D, as well as other autoimmune disorders, suggest that there are defects in Treg-mediated suppression. Indeed, while Treg frequency in the peripheral blood of T1D patients is unaltered, their suppressive abilities are diminished compared to Tregs in healthy controls. Although expression of the transcription factor Foxp3 is a prerequisite for Treg development and function, there are many additional factors that can alter their stability, survival and function. Much has been learned in other model systems, such as tumors, about the mechanism and pathways that control Treg stability and function. This review poses the question: can we use these findings to develop new therapeutic approaches that might boost Treg stability, survival and/or function in T1D, and possibly other autoimmune disorders?

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Section: Loss Of Treg Phenotype and Function In T1d And Autoimmune DImentioning

confidence: 96%

Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?

Visperas

Vignali

2016

The Journal of Immunology

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“…Treg cell is another subset of T helper cells and has also been shown to be involved in diabetes. Clinical and animal studies have demonstrated that the diabetic subjects usually had decreased Treg cell activity and low levels of Treg-related cytokines (24). Enhancement of Treg cell activity, either by adoptive transfer or supplementation of supporting cytokines, such as IL-2, is considered as one of the therapeutic methods to diabetes (25,26).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Ameliorates Diabetes-induced Renal Damage through Regulating the Expression of TGF-B1, Collagen IV and Th17/Treg Related Cytokines in Rats

Zhou

Gao

2014

West Indian Med J

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Objectives: This study aimed at detecting the protective effects of resveratrol on diabetes-induced renal damage and on the expression of transforming growth factor-beta 1 , collagen IV and Th17/Tregrelated and in serum and in the supernatant of the kidney homogenate were determined using ELISA. Results: Diabetic rats had damaged renal function, higher levels of TGF-β1, collagen IV, IL-17A and IL-25, as well as lower levels of IL-35 and IL-10, when compared to the control rats. Compared to the diabetic rats without resveratrol treatment, application of resveratrol to the diabetic rats ameliorated the renal function, inhibited the expression of TGF-β1, collagen IV, IL-17A and IL-25, and increased the expression IL-35 and IL-10. Conclusion: Resveratrol might ameliorate diabetes-induced renal damage through mediating the balance of Th17/Treg-related cytokines and inhibiting the expression of TGF-β1 and collagen IV. Keywords

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“…Multiple sclerosis, psoriasis, Type I diabetes and also AChR-MG patients show a significant decrease in the suppressive function of Tregs compared with HC [10,[67][68][69]. This section focuses on discussing the several studies that have been undertaken on characteristic, quantitative and qualitative changes of Tregs in MG patients.…”

Section: Studies Of Tregs In Patients With Mgmentioning

confidence: 99%

The role of T regulatory cells in immunopathogenesis of myasthenia gravis: implications for therapeutics

Alahgholi-Hajibehzad

Kasapoğlu

Jafari

et al. 2015

Expert Review of Clinical Immunology

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T regulatory cells (Tregs) are crucial for the development of self-tolerance and are the major focus in many studies interpreting the pathogenesis of myasthenia gravis (MG), an autoimmune-based disease. In normal conditions, Tregs regulate the immune responses, while impaired regulatory function of these cells can lead to autoimmunity. Recent studies have confirmed that the thymic and peripheral blood CD4(+)CD25(+) Tregs of MG are defective in functions and/or in numbers, which are associated with disease severity; approaches to correct the defects of these Tregs may be promising in the treatment of MG. This review discusses recent studies on characteristics, quantitative and qualitative changes of Tregs and possible mechanisms that are involved in the impairment of these cells in MG pathogenesis. In addition, new approaches inducing Treg generation that are currently being investigated as therapies for MG, will be discussed as well as proposed approaches for future therapies.

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CD4+CD45RA−FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes

Cited by 85 publications

References 36 publications

Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?

Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?

Resveratrol Ameliorates Diabetes-induced Renal Damage through Regulating the Expression of TGF-B1, Collagen IV and Th17/Treg Related Cytokines in Rats

The role of T regulatory cells in immunopathogenesis of myasthenia gravis: implications for therapeutics

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