CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers

Kono, Koji; Kawaida, Hiromichi; Takahashi, Akihiro; Sugai, Hidemitsu; Mimura, Kosaku; Miyagawa, N; Omata, Hideo; Fujii, Hideki

doi:10.1007/s00262-005-0092-8

Cited by 259 publications

(188 citation statements)

References 24 publications

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“…We have reported that the frequency of T regs among TILs, tumourdraining regional lymph nodes, and peripheral blood lymphocytes is higher in gastric and oesophageal cancer patients than that in their normal counterparts (Ichihara et al, 2003). Importantly, after patients received curative resections of gastric cancers, the increased proportion of T regs was significantly reduced, and the levels were almost equal to those in normal healthy donors (Kono et al, 2006). These results strongly suggest that tumour-related factors induce and expand T regs.…”

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confidence: 73%

Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

et al. 2007

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It has been reported that the population of regulatory T cells (T regs) is increased in tumour-infiltrating lymphocytes in cancer-bearing hosts. Recently, forkhead/winged helix transcription factor p3, Foxp3, is thought to be the most reliable marker of T regs. In the present study, we investigated the prevalence and localisation pattern of Foxp3 þ cells in gastric cancer (n ¼ 80) by immunohistochemistry, in relation to the clinical outcome of gastric cancer patients. Immunohistochemical staining was performed with anti-Foxp3 mAb, and Foxp3 þ cells were semiquantified. We divided all cases into two groups: Foxp3 þ -high (n ¼ 40) and Foxp3 þ -low (n ¼ 40) groups, by the median size of the population of Foxp3 þ cells. Furthermore, in terms of the localisation pattern of accumulating Foxp3 þ cells in tumours, we classified all cases into three groups: a peri-tumour group (n ¼ 30), a diffuse group (n ¼ 40), and a follicular group (n ¼ 10). As a result, although the populations of Foxp3 þ cells in stage IV were significantly larger than those in stage I (Po0.05), there was no significant difference in survival between the patients with high and low population levels of Foxp3 þ cells. However, survival in patients with a diffuse pattern of Foxp3 þ cells was significantly poorer than in those with a peritumoral pattern. In conclusion, the localisation pattern, but not the population size, of Foxp3 þ cells was significantly related to patient survival.

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confidence: 73%

Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

et al. 2007

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“…Thus, the immunosuppression is produced. This suggests that high expression of Treg cells can promote the development of tumor, and affect the prognosis for patients (Woo et al, 2001;Gray et al, 2003;Kono et al, 2006;Hiraoka et al, 2006;Kobayashi et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

CD4⁺, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

Zhang¹,

Han²,

Fang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Human natural Treg cells constitutively express a high level of CD25 (15,(31)(32)(33)(34) and the nuclear transcription factor Foxp3 (10,35,36). Thus, the expression of Foxp3 and LAG-3 inside the CD4 + CD25 high gated cells was evaluated by multiparametric flow cytometry.…”

Section: Resultsmentioning

confidence: 99%

LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites

Camisaschi¹,

Casati²,

Rini³

et al. 2010

The Journal of Immunology

279

199

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CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers

Abstract: These results strongly suggest that tumor-related factors induce and expand CD4(+)CD25high T regs.

Cited by 259 publications

References 24 publications

Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

CD4⁺, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites

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CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers

Abstract: These results strongly suggest that tumor-related factors induce and expand CD4(+)CD25high T regs.

Cited by 259 publications

References 24 publications

Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer

CD4+, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites

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CD4⁺, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis