CD4+ CD25+ T-regulatory cells in psoriasis. Correlation between their numbers and biologics-induced clinical improvement

Richetta, Antonio Giovanni; Mattozzi, Carlo; Salvi, Monica; Giancristoforo, Simona; D'Epiro, S; Milana, Bernardina; Carboni, Valentina; Zampetti, M; Calvieri, Stefano; Morrone, Stefania

doi:10.1684/ejd.2011.1362

Cited by 44 publications

(38 citation statements)

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“…On the other hand, regulatory T cells play a crucial role in the processes of peripheral tolerance and are pivotal for controlling the outgrowth of potentially pathogenic self-reactive T cells [28]. Lower levels of Treg cells in both skin and peripheral blood have been shown in progressive disease while higher levels were found in stable or regressive lesions [53, 54]. In the present study, Treg levels at baseline were lower, though not significantly, than those found in the reference group.…”

Section: Discussionmentioning

confidence: 99%

Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis

Cordiali‐Fei

Bianchi

Bonifati

et al. 2014

Mediators of Inflammation

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Background. The therapeutic management of psoriasis includes conventional treatments as well as the new generation of highly effective TNF-α inhibitors. However, psoriasis has proven to be a complex therapeutic challenge and treatment failures are not uncommon. Thus, laboratory biomarkers of disease progression/therapeutic efficacy may greatly help in the clinical management of psoriasis. Aims. To identify laboratory biomarkers for clinical management and therapeutic monitoring of psoriasis. Methods. An observational study performed on 59 patients, presenting moderate to severe psoriasis, undergoing treatment with anti-TNF-α agents (etanercept, adalimumab, and infliximab). Soluble and cellular immune/inflammatory parameters were assessed at baseline and after 12 and 24 weeks of treatment. Results. Clinical efficacy was achieved in 88% of the subjects at 12 weeks, reaching 90% after 24 weeks. IL-6 and IL-22, which were elevated at baseline, were significantly reduced, in association with a significant decrease of CLA+ T cells and an increase of Treg lymphocytes. T, B, and NK cell subsets and T cell response to recall antigens did not show any evidence of immune suppression. Conclusions. Immune/inflammatory parameters including IL-6 and IL-22, CLA+ T cells, and Treg lymphocytes may prove to be valuable laboratory tools for the clinical and therapeutic monitoring of psoriasis.

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Section: Discussionmentioning

confidence: 99%

Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis

Cordiali‐Fei

Bianchi

Bonifati

et al. 2014

Mediators of Inflammation

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“…5 This suppressive and regulatory function is performed by regulatory T cells (Treg), which are CD3 + CD4 + CD25 high6 . [9][10][11][12] Budiu et al 13 demonstrated increased Foxp3 expression in six of nine ovarian endometrioma samples, compared to only one of six benign ovarian cysts, suggesting the recruitment of those cells by endometriotic lesions. 7,8 The transcription factor Foxp3 (Forkhead box protein P3) is an essential molecule for the regulatory function of these cells.…”

Section: Introductionmentioning

confidence: 99%

CD4⁺CD25^highFoxp3⁺ Cells Increased in the Peritoneal Fluid of Patients with Endometriosis

Podgaec

Rizzo

Fernandes

et al. 2012

American J Rep Immunol

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Problem To evaluate CD4+CD25highFoxp3+ cells and IL‐6, IL‐10, IL‐17, and TGF‐β in the peritoneal fluid of women with endometriosis. Method of study A total of ninety‐eight patients were studied: endometriosis (n = 70) and control (n = 28). First, peritoneal fluid lymphocytes were isolated, and CD4+CD25high cells were identified using flow cytometry. Then, RT‐PCR was performed to verify Foxp3 expression in these cells. Also, IL‐6, IL‐10, IL‐17, and TGF‐β concentration was determined. Results Of all the lymphocytes in the peritoneal fluid of women with endometriosis, 36.5% (median) were CD4+CD25high compared to only 1.15% (median) in the control group (P < 0.001). Foxp3 expression was similarly elevated in patients with the disease compared to those without (median, 50 versus 5; P < 0.001). IL‐6 and TGF‐β were higher in endometriosis group (IL‐6: 327.5 pg/mL versus 195.5 pg/mL; TGF‐β: 340 pg/mL versus 171.5 pg/mL; both P < 0.001). IL‐10 and IL‐17 showed no significant differences between the two groups. Conclusion The peritoneal fluid of patients with endometriosis had a higher percentage of CD4+CD25highFoxp3+ cells and also higher levels of IL‐6 and TGF‐β compared to women without the disease. These findings suggest that CD4+CD25highFoxp3+ cells may play a role in the pathogenesis of endometriosis.

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“…It is likely that this Treg defect may be induced by IL-6, produced in psoriatic lesions by activated dendritic cells and Th17 cells; in vitro, IL-6 is sufficient to prevent Treg suppression of effector T-cell proliferation [40]. Also, in some psoriasis patients, treatment with anti-tumor necrosis factor-a (TNF-a) therapy leads to resolution of disease symptoms, correlating with a restoration of circulating Tregs to the level found in healthy controls [41]. Recently, it was also shown that Foxp3 þ Tregs from psoriasis patients are able to convert into IL-17-producing cells [42].…”

Section: Regulatory T Cells In Inflammatory Bowel Disease and Psoriasismentioning

confidence: 99%

Dendritic cells and regulatory T cells in spondyloarthritis

Wright

Utriainen

Milling

2013

Current Opinion in Rheumatology

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Although defects in Tregs are important in psoriasis and in animal models of IBD, there is little evidence that they are important in SpA. However, data from animal models indicate that dendritic cells drive pathogenic T-cell responses, partly through the production of interleukin-23 (IL-23). Dendritic cells from SpA patients may also contribute to disease by producing IL-23, therefore supporting the differentiation of the Th17 cells that contribute to inflammation. The driving forces in SpA pathophysiology are now becoming clear; these data may lead to the development of novel therapies to target SpA and related inflammatory disorders.

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CD4+ CD25+ T-regulatory cells in psoriasis. Correlation between their numbers and biologics-induced clinical improvement

Cited by 44 publications

References 0 publications

Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis

Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis

CD4⁺CD25^highFoxp3⁺ Cells Increased in the Peritoneal Fluid of Patients with Endometriosis

Dendritic cells and regulatory T cells in spondyloarthritis

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CD4+ CD25+ T-regulatory cells in psoriasis. Correlation between their numbers and biologics-induced clinical improvement

Cited by 44 publications

References 0 publications

Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis

Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis

CD4+CD25highFoxp3+ Cells Increased in the Peritoneal Fluid of Patients with Endometriosis

Dendritic cells and regulatory T cells in spondyloarthritis

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CD4⁺CD25^highFoxp3⁺ Cells Increased in the Peritoneal Fluid of Patients with Endometriosis