CD4+CD25+ naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune thyroiditis in NOD-H2h4 mice

Nagayama, Yuji; Horie, Ichiro; Saitoh, Ohki; Nakahara, Mami; Abiru, Norio

doi:10.1016/j.jaut.2007.07.008

Cited by 57 publications

(49 citation statements)

References 40 publications

(42 reference statements)

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“…In many autoimmune diseases, Treg play a key role in controlling these deleterious responses as demonstrated in both mouse models and human immune deficiencies where loss of molecules essential for Treg survival and function lead to pathology [14,37,38]. In mouse models, autoimmunity can be both prevented and treated by adoptive transfer of competent Treg.…”

Section: Discussionmentioning

confidence: 99%

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

Long¹,

Buckner²

2008

Journal of Autoimmunity

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The immune system protects itself from autoreactivity by maintaining a balance between effector and Treg responses. Peripheral induction of Treg is one mechanism by which this balance may be maintained. Thus, it is important to understand factors that influence de novo generation of CD4 + CD25 + FOXP3 + Treg. Here, we focus on the effects of cytokines and the cell cycle inhibitor rapamycin. The cytokines IL-2 and IL-7, but not IL-4, increased initial activation induced FOXP3 expression, increased proliferation and sustained expression of FOXP3 + cells throughout the culture. Addition of rapamycin to cultures containing IL-2 further increased the frequency and absolute number of functional CD4 + CD25 + FOXP3 + Treg. This increase was not due to selective proliferation of FOXP3 cells, but was instead, the result of an increase in the frequency of FOXP3 + cells induced in G0 through delayed activation while the addition of IL-2 promoted survival and proliferation of the FOXP3 + population. Thus, combination of rapamycin and IL-2 may provide improved treatment options in transplantation and autoimmunity by promoting induction, survival, and expansion of functional iTreg from CD4 + CD25 − cells.

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Section: Discussionmentioning

confidence: 99%

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

Long¹,

Buckner²

2008

Journal of Autoimmunity

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“…Depletion of Treg cells rendered some C57BL/6 mice susceptible to induction of GD (1,2). In untreated GD patients, the percentage of circulating CD4 C…”

Section: Introductionmentioning

confidence: 99%

Function of regulatory T-cells improved by dexamethasone in Graves' disease

Tian

Zhang

et al. 2012

European Journal of Endocrinology

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“…In the present study, we found that NOD. mice by treating with anti-CD25 antibody 4 days before the initiation of NaI supplementation increases the severity of thyroiditis and TgAb titers [17]. B cell-deficient NOD.H-2 h4 mice are AIT resistant and do not develop AIT even when reconstituted with B cells or given passive anti-murine Tg autoantibodies.…”

Section: Discussionmentioning

confidence: 99%

Selenium upregulates CD4+CD25+ regulatory T cells in iodine-induced autoimmune thyroiditis model of NOD.H-2h4 mice

Xue

Wang

et al. 2010

Endocr J

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CD4+CD25+ naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune thyroiditis in NOD-H2h4 mice

Cited by 57 publications

References 40 publications

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

Function of regulatory T-cells improved by dexamethasone in Graves' disease

Selenium upregulates CD4<SUP>+</SUP>CD25<SUP>+</SUP> regulatory T cells in iodine-induced autoimmune thyroiditis model of NOD.H-2<SUP>h4</SUP> mice

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