CD4+CD25+FOXP3+ regulatory T cells: a potential “armor” to shield “transplanted allografts” in the war against ischemia reperfusion injury
Shareni Jeyamogan,
Joseph R. Leventhal,
James M. Mathew
et al.
Abstract:Despite the advances in therapeutic interventions, solid organ transplantation (SOT) remains the “gold standard” treatment for patients with end-stage organ failure. Recently, vascularized composite allotransplantation (VCA) has reemerged as a feasible treatment option for patients with complex composite tissue defects. In both SOT and VCA, ischemia reperfusion injury (IRI) is inevitable and is a predominant factor that can adversely affect transplant outcome by potentiating early graft dysfunction and/or graf… Show more
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