1999
DOI: 10.1097/00007890-199904150-00971
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Cd4+/Cd25+ Cells Regulate Cd8 Cell Anergy in Tolerant Mice

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Cited by 19 publications
(29 citation statements)
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“…In the present experiments, the addition of exogenous IL-2 to cultures containing human CD4reg restored CD8 CTL activity partially but not completely. This result is consistent with the role of CD4 ϩ CD25 ϩ cells in sustaining transplantation tolerance (18).…”
Section: Discussionsupporting
confidence: 90%
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“…In the present experiments, the addition of exogenous IL-2 to cultures containing human CD4reg restored CD8 CTL activity partially but not completely. This result is consistent with the role of CD4 ϩ CD25 ϩ cells in sustaining transplantation tolerance (18).…”
Section: Discussionsupporting
confidence: 90%
“…These workers injected semiallogeneic splenocytes into neonatal mice and observed long term Ag-specific CD8 cell nonresponsiveness. Interestingly, although IL-2 could not restore CD8 CTL activity, this result was achieved after removal of regulatory CD4 ϩ CD25 ϩ T cells from the cell suspensions (18). Thus, as long as regulatory T cells were present, even IL-2 could not reverse anergy.…”
Section: Discussionmentioning
confidence: 96%
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“…Our observation that CD8 ϩ T cells from neonatally tolerant mice are able to suppress the response to donor alloantigens is consistent with a previous report demonstrating that anti-donor CD8 ϩ T cells persist after neonatal induction of transplantation tolerance but are suppressed by CD4 ϩ T cells with regulatory properties (33). Because we found that anti-donor CD4 ϩ Th2 activities are themselves inhibited by CD8 ϩ T cells, one can conclude that CD4 ϩ and CD8 ϩ T cell responses against donor alloantigens are indeed cross-regulated in allotolerant mice.…”
Section: Discussionsupporting
confidence: 93%
“…Although the exact mechanism for the apparent selective maintenance of the Th2 cells is unknown, it has been suggested that the primary Th1 cells that arise upon neonatal exposure to Ag are more vulnerable to apoptosis (8). Also, recent investigations have envisioned the involvement of regulatory (9) and CD4 ϩ Thy1 Ϫ (10) T cells to maintain such biased neonatal immunity. Furthermore, although neonatal tolerance has proved effective in conferring resistance against autoimmunity (11)(12)(13)(14), the mechanism initiating and perpetuating the biased neonatal immunity is still undefined.…”
mentioning
confidence: 99%