CD39 identifies a specific CD8+T cell population in EGFR- driven lung adenocarcinoma related metastatic pleural effusion
Leilei Lv,
Hong Wang,
Yao-xin Zhang
et al.
Abstract:Malignant pleural effusion (MPE) is common in lung cancer, which was a complex microenvironment containing a plethora of immune and tumor signals. Gene alterations such as driver gene mutations were considered to affect the components in the TIME of non-small-cell lung cancer (NSCLC). Here, we demonstrated that pleural CD39+CD8+T cells were selectively elevated in firstly-diagnosed lung adenocarcinoma with wild-type epidermal growth factor receptor (EGFRwt) compared to that in mutant epidermal growth factor re… Show more
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