CD39 expression by regulatory T cells drives CD8+ T cell suppression during experimentalTrypanosoma cruziinfection
Cintia L. Araujo Furlan,
Santiago Boccardo,
Constanza Rodriguez
et al.
Abstract:An imbalance between suppressor and effector immune responses may preclude cure in chronic parasitic diseases. In the case of Trypanosoma cruzi infection, specialized regulatory Foxp3+ T (Treg) cells suppress protective type-1 effector responses. Herein, we investigated the kinetics and underlying mechanisms behind the regulation of protective parasite-specific CD8+ T cell immunity during acute T. cruzi infection. Using the DEREG mouse model, we found that Treg cells play a critical role during the initial sta… Show more
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