CD34‐reactive tumors of the skin. An updated review of an ever‐growing list of lesions

Tardío, Juan C.

doi:10.1111/j.1600-0560.2008.01212.x

Cited by 73 publications

(69 citation statements)

References 164 publications

(198 reference statements)

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“…PHAT might be misdiagnosed as other soft tissue lesions because of its rarity. Malignant fibrous histiocytoma and neurilemoma should be considered as differential diagnosis, as cellular pleomorphism and ectatic, hyalinized blood vessels with infiltration of variable chronic inflammatory cells could be present in above tumors [2][3][4][5]. Characteristic features of neurilemoma like palisading of nuclei with formation of verrocay bodies are absent in PHAT.…”

Section: Case Reportmentioning

confidence: 99%

“…Characteristic features of neurilemoma like palisading of nuclei with formation of verrocay bodies are absent in PHAT. Immunohistochemically, PHAT is strongly positive for CD34, VEGF, CD99 and negative for S-100 protein [1,5]. Surgical excision with tumor-free margin is the treatment of choice for this lesion as it has a considerable potential for local recurrence [2].…”

Section: Case Reportmentioning

confidence: 99%

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Pleomorphic hyalinizing angiectatic tumor of soft parts involving the upper limb

et al. 2010

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Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts is a low grade, rare, soft tissue tumor which commonly occurs on the lower extremities of adults of either sex, though lesions in other anatomic locations have been described. We present a case of a 65-year-old female patient who presented with a left forearm swelling and underwent a wide local excision. Histopathology revealed it to be a PHAT.

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Pleomorphic hyalinizing angiectatic tumor of soft parts involving the upper limb

et al. 2010

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“…It was called desmoplastic trichilemmoma. As a manifestation of their differentiation towards the outer sheath of the hair root, trichilemmomas, both conventional and desmoplastic types express CD34, a feature that has been used in their differential diagnosis with other epithelial tumors [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Trichilemmoma Arising in the Nasal Vestibule: Report of Three Cases with Special Emphasis on the Differential Diagnosis

Herráiz

Martín-Fragueiro

Tardío

2012

Head and Neck Pathol

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Trichilemmoma is a benign cutaneous epithelial tumor with differentiation towards cells of the outer hair root sheath and usually presents as a small papule on the face of middle-aged or older adults. We herein report three cases of trichilemmoma located in the nasal vestibule, including two of the conventional type and one of the desmoplastic variant. To our knowledge, only one case of trichilemmoma arising in the nasal vestibule has been previously reported. Trichilemmoma must be included in the differential diagnosis of epithelial lesions arising in this location. This is particularly important in the case of the desmoplastic trichilemmoma, a tumor that resembles invasive carcinoma such as desmoplastic squamous cell carcinoma, sclerosing basal cell carcinoma, and trichilemmal carcinoma. The circumscription of the lesion, the architectural pattern of epithelial cell cords and small nests merging with a desmoplastic stroma in the central area of the tumor, the expression of CD34, and the lack of an obvious squamous differentiation or basaloid foci favor the diagnosis of desmoplastic trichilemmoma. All these features help to rule out the diagnosis of carcinoma with significant clinical implications.

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“…It is also an endothelial marker and stains solitary fibrous tumor, spindle cell lipoma, superficial acral fibromyxoma, sclerotic fibroma, Kaposi sarcoma, neurofibroma, tricholemmoma, scleromyxedema, and nephrogenic systemic fibrosis, among others. [241][242][243] Factor XIIIa is typically weak and only identified at the periphery of DF or more diffusely in spindle cell-dominant cellular DFs. 237 Many alternative markers have been explored but mostly in isolated studies with few cases.…”

Section: Dermatofibroma and Dfspmentioning

confidence: 99%

Immunohistochemistry in Dermatopathology

Ferringer

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Immunohistochemistry is not a diagnostic test but a highly valuable tool that requires interpretation within a context.Objective.-To review the current status and limitations of immunohistochemistry in dermatopathology.Data Sources.-English-language literature published between 1980 and 2014.Conclusions.-Although immunohistochemistry is rarely completely specific or sensitive, it is an important adjunctive technique in dermatopathology and can be helpful in a series of diagnostic dilemmas.

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CD34‐reactive tumors of the skin. An updated review of an ever‐growing list of lesions

Cited by 73 publications

References 164 publications

Pleomorphic hyalinizing angiectatic tumor of soft parts involving the upper limb

Pleomorphic hyalinizing angiectatic tumor of soft parts involving the upper limb

Trichilemmoma Arising in the Nasal Vestibule: Report of Three Cases with Special Emphasis on the Differential Diagnosis

Immunohistochemistry in Dermatopathology

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