CD34 Protein: Its expression and function in inflammation

Rodrigues, Carolina Rego; Moga, Sahib; Singh, Baljit; Aulakh, Gurpreet Kaur

doi:10.1007/s00441-023-03811-4

Cited by 4 publications

(2 citation statements)

References 83 publications

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“…Still, its dysregulation could influence intracellular signaling, potentially affecting the overall stress response. CD34, a well-known marker of hematopoietic stem cells, might suggest an increased effort to replenish damaged blood cells from nitrite-induced oxidative stress [60]. FARSB, involved in protein synthesis, may be related to the increased demand for protein turnover under stress conditions, where damaged proteins need to be replaced [61].…”

Section: Discussionmentioning

confidence: 99%

The bZIP Transcription Factor Family Orchestrates the Molecular Response to Nitrite Stress in the Largemouth Bass Spleen

Sun,

Huang,

Wang

et al. 2023

Fishes

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Nitrite toxicity poses a significant threat to aquatic organisms, including largemouth bass (LMB) and Micropterus salmoides. This study aimed to elucidate the role of bZIP transcription factors in mediating the molecular responses to nitrite stress in the LMB spleen. We identified 120 bZIP genes in the LMB genome using bioinformatics analysis and divided them into 11 subgroups based on phylogenetic relationships. Under nitrite stress, the bZIP_XI subgroup was upregulated, suggesting the activation of the stress response in the LMB spleen. Cellular pathway analysis revealed enrichment of pathways related to stress response, DNA repair, apoptosis, and autophagy. Co-expression network analysis highlighted bZIP_XI members such as msabZIP_49, msabZIP_12, msabZIP_39, and msabZIP_116 as potential key regulators. These transcription factors likely modulated the expression of stress-related genes like VCAM1, POLE3, and BMP1. Conserved binding motifs in the promoters of these genes may support regulation by bZIP_XI. Furthermore, bZIP_XI members correlated with immune cell infiltration in the spleen, potentially regulating immune-related genes like BCL2L1 and SELE. Homologs of bZIP_XI in other fish species exhibited similar expression patterns under stress. Overall, this study implicates the bZIP transcription factor family, notably the bZIP_XI subgroup, in orchestrating the molecular response of the LMB spleen to nitrite toxicity by regulating stress response pathways and immune function. These findings provide insights into nitrite stress adaptation in fish.

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Section: Discussionmentioning

confidence: 99%

The bZIP Transcription Factor Family Orchestrates the Molecular Response to Nitrite Stress in the Largemouth Bass Spleen

Sun,

Huang,

Wang

et al. 2023

Fishes

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“…In the present study, we combined this method of visualizing renal tubules with the addition of a CD34 as a marker for endothelial cells and blood vessels. CD34 is a transmembrane glycoprotein encoded by the gene CD34, specifically expressed in hematopoietic progenitor cells and endothelial cells (Hassanpour et al, 2023;Rodrigues et al, 2023). A previous immunohistochemical study showed that anti-CD34 antibodies stain the glomerular capillaries in human kidneys (Pusztaszeri et al, 2006).…”

mentioning

confidence: 99%

Mapping the cytoskeletal architecture of renal tubules and surrounding peritubular capillaries in the kidney

Kumaran,

Hanukoglu

2023

Cytoskeleton

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The human kidney includes ~1 million nephrons which are long U‐shaped tubules with convoluted segments that serve as filtration units. During the passage of the ultrafiltrate through a nephron, electrolytes and nutrients are re‐absorbed into peritubular capillaries. The fluid remaining in the distal end of the renal tubules flows through the collecting ducts into the ureter. In this study, we generated high‐resolution images of mouse kidney sections using confocal microscopy with only two fluorescently tagged biomarkers, F‐actin binding phalloidin and CD34 antibodies as a marker for blood vessels. In tile‐scan images of entire sections of mouse kidney (composed of >1000 images), the tubule segments are easily identifiable by their F‐actin bundles on cell borders and the outlines of the peritubular capillaries by CD34 immunofluorescence. In the inner stripe of the medulla, the vascular bundles composed of vasa recta (straight vessels) could be easily distinguished from the peritubular capillaries by their full circular shapes. The highly vascular inner medulla and the papilla similarly have straight capillaries. About 95% of kidney volume is composed of renal tubules and blood vessels. Thus, our results show that relatively simple cytoskeletal mapping can be used to visualize the structural organization of the kidney. This method can also be applied to examine pathological changes in the kidney.

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Utilizing machine learning to integrate single-cell and bulk RNA sequencing data for constructing and validating a novel cell adhesion molecules related prognostic model in gastric cancer

Chen,

et al. 2024

Computers in Biology and Medicine

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CD34 Protein: Its expression and function in inflammation

Cited by 4 publications

References 83 publications

The bZIP Transcription Factor Family Orchestrates the Molecular Response to Nitrite Stress in the Largemouth Bass Spleen

The bZIP Transcription Factor Family Orchestrates the Molecular Response to Nitrite Stress in the Largemouth Bass Spleen

Mapping the cytoskeletal architecture of renal tubules and surrounding peritubular capillaries in the kidney

Utilizing machine learning to integrate single-cell and bulk RNA sequencing data for constructing and validating a novel cell adhesion molecules related prognostic model in gastric cancer

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