CD34 Is Required for Dendritic Cell Trafficking and Pathology in Murine Hypersensitivity Pneumonitis

Blanchet, Marie‐Renée; Bennett, Jami; Gold, Matthew; Tenen, Daniel G.; Girard, M; Cormier, Yvon; McNagny, Kelly M.

doi:10.1164/rccm.201011-1764oc

Cited by 36 publications

(28 citation statements)

References 42 publications

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“…Dendritic cell trafficking is a pivotal mechanism in many inflammatory lung diseases. Blanchet and colleagues (58) demonstrate the requirement for stem cell antigen, CD34, in trafficking of dendritic cells from the circulation into the alveoli and, from there through the lung parenchyma, to draining lymph nodes in a murine hypersensitivity pneumonitis model (58). In this study, CD34-deficient mice are protected from hypersensitivity pneumonitis.…”

Section: Hypersensitivity Pneumonitismentioning

confidence: 58%

Update in Diffuse Parenchymal Lung Disease 2011

Luckhardt¹,

Müller–Quernheim²,

Thannickal³

2012

Am J Respir Crit Care Med

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Section: Hypersensitivity Pneumonitismentioning

confidence: 58%

Update in Diffuse Parenchymal Lung Disease 2011

Luckhardt¹,

Müller–Quernheim²,

Thannickal³

2012

Am J Respir Crit Care Med

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“…The fact that expression of a human transgene was able to rescue the disease phenotype in these mice suggests that the human gene functions in a similar fashion [30] . While, at face value, it is difficult to reconcile the different roles for CD34 (and Podxl) observed in proliferation and cell migration, it should be noted that these may not be mutually exclusive; it is possible that CD34 plays subtle roles in both pathways.…”

Section: The Cd34 Family Of Sialomucins: Structure and Functionsmentioning

confidence: 97%

“…+ dendritic cell precursors [30] . The fact that expression of a human transgene was able to rescue the disease phenotype in these mice suggests that the human gene functions in a similar fashion [30] .…”

Section: The Cd34 Family Of Sialomucins: Structure and Functionsmentioning

confidence: 99%

“…However, in addition to their overlapping expression on these cell types, these molecules are also uniquely expressed on other cells. In the case of CD34, it is uniquely expressed by inflammatory cell precursors (mast cells, eosinophils and dendritic cells) and has been shown to be important for facilitating cell trafficking and the development of mucosal inflammatory disease, while in its absence, mice are rendered remarkably resistant to a range of disease including allergic asthma, hypersensitivity pneumonitis, colitis, Salmonella induced inflammation, and colon cancer [30][31][32][33][34] . As already mentioned in the introduction, CD34 is expressed by various stem/progenitor cells such as muscle satellite cells, adipogenic precursors and by hair follicle and keratinocyte stem cells.…”

Section: The Cd34 Family Of Sialomucins: Structure and Functionsmentioning

confidence: 99%

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A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue

Scherberich

Maggio²,

McNagny³

2013

WJSC

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Human adipose tissue obtained by liposuction is easily accessible and an abundant potential source of autologous cells for regenerative medicine applications. After digestion of the tissue and removal of differentiated adipocytes, the so-called stromal vascular fraction (SVF) of adipose, a mix of various cell types, is obtained. SVF contains mesenchymal fibroblastic cells, able to adhere to culture plastic and to generate large colonies in vitro , that closely resemble bone marrow-derived colony forming units-fibroblastic, and whose expanded progeny, adipose mesenchymal stem/stromal cells (ASC), show strong similarities with bone marrow mesenchymal stem cells. The sialomucin CD34, which is well known as a hematopoietic stem cell marker, is also expressed by ASC in native adipose tissue but its expression is gradually lost upon standard ASC expansion in vitro . Surprisingly little is known about the functional role of CD34 in the biology and tissue forming capacity of SVF cells and ASC. The present editorial provides a short introduction to the CD34 family of sialomucins and reviews the data from the literature concerning expression and function of these proteins in SVF cells and their in vitro expanded progeny.

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“…As noted above, CD34 has been shown to play a key role in the trafficking of HSPCs to the appropriate sites of hematopoiesis in transplantation assays. [113][114][115] Although targeted deletion of the Cd34 gene in mice by two groups yields only very subtle phenotypes at steady state, 116,117 it has also been shown that these mice are refractory to a variety of mucosal inflammatory diseases including allergic asthma, 116,118 hypersensitivity pneumonitis, 119 colitis, 120 salmonella infection, 121 and intestinal polyposis. 122,123 This appears to be through a general role for CD34 in blocking adhesion and enhancing mobility, and also through a highly selective role in enhancing chemotaxis to a subset of chemokines.…”

Section: Anti-cd34mentioning

confidence: 99%

In situ hematopoiesis: a regulator of TH2 cytokine-mediated immunity and inflammation at mucosal surfaces

et al. 2015

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Hematopoiesis refers to the development of blood cells in the body through the differentiation of pluripotent stem cells. Although hematopoiesis is a multifocal process during embryonic development, under homeostatic conditions it occurs exclusively within the bone marrow. There, a limited number of hematopoietic stem cells differentiate into a rapidly proliferating population of lineage-restricted progenitors that serve to replenish circulating blood cells. However, emerging reports now suggest that under inflammatory conditions, alterations in hematopoiesis that occur outside of the bone marrow appear to constitute a conserved mechanism of innate immunity. Moreover, recent reports have identified previously unappreciated pathways that regulate the egress of hematopoietic progenitor cells from the bone marrow, alter their activation status, and skew their developmental potential. These studies suggest that progenitor cells contribute to inflammatory response by undergoing in situ hematopoiesis (ISH). In this review, we highlight the differences between homeostatic hematopoiesis, which occurs in the bone marrow, and ISH, which occurs at mucosal surfaces. Further, we highlight factors produced at local sites of inflammation that regulate hematopoietic progenitor cell responses and the development of TH2 cytokine-mediated inflammation. Finally, we discuss the therapeutic potential of targeting ISH in preventing the development of inflammation at mucosal sites.

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CD34 Is Required for Dendritic Cell Trafficking and Pathology in Murine Hypersensitivity Pneumonitis

Cited by 36 publications

References 42 publications

Update in Diffuse Parenchymal Lung Disease 2011

Update in Diffuse Parenchymal Lung Disease 2011

A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue

In situ hematopoiesis: a regulator of TH2 cytokine-mediated immunity and inflammation at mucosal surfaces

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