CD34+ cell of origin for immunoglobulin heavy chain variable region unmutated, but not mutated, chronic lymphocytic leukemia

Perkins, Brandy; Showel, Margaret M.; Schoch, Laura; Imus, Philip; Karantanos, Theodoros; Yonescu, Raluca; Morsberger, Laura; Ghiaur, Gabriel; Gladstone, Douglas E.; Jones, Richard J.

doi:10.1080/10428194.2022.2038375

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…The cellular origin of CLL is still unclear. Process of B cell maturation is complex and involves many different stages where the initial mutation may start the CLL leukemogenesis (234)(235)(236)(237)(238). One of the models assumes the involvement of HSPCs in CLL pathogenesis.…”

Section: Hsc and Chronic Lymphocytic Leukemiamentioning

confidence: 99%

The dark side of stemness – the role of hematopoietic stem cells in development of blood malignancies

Filipek-Gorzała,

Kwiecińska,

Szade

et al. 2024

Front. Oncol.

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Hematopoietic stem cells (HSCs) produce all blood cells throughout the life of the organism. However, the high self-renewal and longevity of HSCs predispose them to accumulate mutations. The acquired mutations drive preleukemic clonal hematopoiesis, which is frequent among elderly people. The preleukemic state, although often asymptomatic, increases the risk of blood cancers. Nevertheless, the direct role of preleukemic HSCs is well-evidenced in adult myeloid leukemia (AML), while their contribution to other hematopoietic malignancies remains less understood. Here, we review the evidence supporting the role of preleukemic HSCs in different types of blood cancers, as well as present the alternative models of malignant evolution. Finally, we discuss the clinical importance of preleukemic HSCs in choosing the therapeutic strategies and provide the perspective on further studies on biology of preleukemic HSCs.

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Section: Hsc and Chronic Lymphocytic Leukemiamentioning

confidence: 99%

The dark side of stemness – the role of hematopoietic stem cells in development of blood malignancies

Filipek-Gorzała,

Kwiecińska,

Szade

et al. 2024

Front. Oncol.

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“…The search for CLL initiating cells has never been successful (Front Oncol 2018). The CLL cell of origin remains controversial, and although CLL is thought to originate from mature B-cells, some subtypes may be derived from a less mature B-cell lineage (Perkins et al 2022).…”

Section: Cells At Riskmentioning

confidence: 99%

Radon-222 and Leukemia

Harley

Leslie²

2023

Health Physics

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Leukemia was the first medically observed human cancer related to ionizing radiation in the 1945 follow-up study of atomic bomb survivors. The bone exposure and dose calculated here are based on the measured solubility of the noble gas 222Rn in blood. A fraction of the 222Rn gas in blood distributes as dissolved gas to all organs, with the fraction depending upon the blood flow rate to the organ. The exposure and dose calculated are for men and women based on measurements made for the blood flow rate to the femur, the largest bone in the human skeleton. The annual exposure and dose estimated for continuous 222Rn inhalation of 100 Bq m−3 are very low and unlikely to cause leukemia. Other neurological issues, from lifetime exposure to low activity concentrations of 222Rn alpha particle exposure in bone, are unknown.

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Next-CLL, a New Next-Generation Sequencing–Based Method for Assessment of IGHV Gene Mutational Status in Chronic Lymphoid Leukemia

Bourbon

Chabane

Mosnier

et al. 2023

The Journal of Molecular Diagnostics

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CD34+ cell of origin for immunoglobulin heavy chain variable region unmutated, but not mutated, chronic lymphocytic leukemia

Cited by 3 publications

References 35 publications

The dark side of stemness – the role of hematopoietic stem cells in development of blood malignancies

The dark side of stemness – the role of hematopoietic stem cells in development of blood malignancies

Radon-222 and Leukemia

Next-CLL, a New Next-Generation Sequencing–Based Method for Assessment of IGHV Gene Mutational Status in Chronic Lymphoid Leukemia

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