CD33+ Immature Myeloid Cells Critically Predict Recurrence in Advanced Gastric Cancer

Soeno, Takafumi; Katoh, Hiroshi; Ishii, Satoru; Ushiku, Hideki; Hosoda, Kei; Hiki, Naoki; Watanabe, Masahiko; Yamashita, Keishi

doi:10.1016/j.jss.2019.07.095

Cited by 10 publications

(8 citation statements)

References 59 publications

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“…However, group A had lower incidence of complications. Due to declining immune function and multiple diseases in elderly patients, there is increased risk of adverse reactions after therapy [18,19].…”

Section: Discussionmentioning

confidence: 99%

Effect of oteracil in combination with gimeracil on longterm survival and postoperative complications in elderly patients undergoing radical surgery for biliary tract cancer

Zhang¹,

Zhang²,

Wu³

et al. 2022

Trop. J. Pharm Res

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Purpose: To investigate the effect of oteracil (Oxo) in combination with gimeracil (CDHP) on long-term survival and postoperative complications in elderly patients undergoing radical surgery for biliary tract cancer (BTC).Methods: Clinical data for 70 patients who underwent radical surgery for BTC in the Oncology Department of the Changle People’s Hospital, Weifang, China from April 2017 to April 2018 were collected. The patients were equally assigned to group A and group B, based on odd or even hospitalization number. After surgery, patients in group A received the combination of Oxo and CDHP, while group B patients received gemcitabine only. Long-term survival and incidence of adverse reactions were compared.Results: Compared with group B, group A had higher total treatment effectiveness (p < 0.05), lower clinical indices (p < 0.05), lower BPI score (p < 0.001) and higher 3-year overall survival (p < 0.05).Conclusion: Combined use of oteracil and gimeracil significantly prolongs the survival time and reduce cancer pain in BTC patients, with minimal toxic and side effects. However, further clinical trials are required prior to application in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Effect of oteracil in combination with gimeracil on longterm survival and postoperative complications in elderly patients undergoing radical surgery for biliary tract cancer

Zhang¹,

Zhang²,

Wu³

et al. 2022

Trop. J. Pharm Res

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“…However, we observed an increase in CD14 − and CD14 − CD33 + in Crohn’s patients when compared with health subjects (p≤0.01) (Fig 2B). The difference in CD33 + cells may indicate an increase in immature cells in the peripheral blood of Crohn’s patients, which may play an important role in the disease resolution not being able to build a proper immune response [35,36] .…”

Section: Methodsmentioning

confidence: 99%

Exhaustion profile on classical monocytes after LPS stimulation in patients with Crohn’s disease

Oliveira,

Xavier,

Nora

et al. 2024

Preprint

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Crohn's disease is an inflammatory bowel disease that induces diarrhea, abdominal pain, weight loss, and even susceptibility to developing tumors. The immune system is pivotal in the gastrointestinal tract, promoting tolerance against commensal antigens and food. However, Crohn's disease manifests by a breakdown in the mechanism of immune tolerance and the consequent development of exacerbated chronic inflammatory responses. The involvement of the immune system is pivotal in Crohn's disease, with a wide range of immune cells being altered, which may include monocytes. Taking the lack of knowledge regarding monocytes in Crohn's disease, we ought to elucidate the cytokine production and activation profile of monocyte subsets in the pathophysiology. We used multiparametric flow cytometry, quantified gene expression using qPCR, and made a correlation matrix regarding flow cytometry data and qPCR using a bioinformatic approach to examine monocyte status. The Corhn's patients show a decrease in all subsets of monocytes. In contrast, classical monocytes show an exhaustion profile with increased expression of CD38 and decreased production of IL-1beta after LPS stimulation in the patients' group. These results indicate that monocyte subsets are differentially involved in the pathophysiology. These findings may suggest that monocytes favor disease chronicity and lack immune response resolution.

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“…However, the global 5-year overall survival (OS) rate remains <15%, which is mainly due to the late diagnosis and lack of early detection of GC (2,3). A high recurrence rate and tendency to metastasize also lead to poor clinical outcomes (4,5).…”

Section: Introductionmentioning

confidence: 99%

Identification of candidate biomarkers associated with gastric cancer prognosis based on an integrated bioinformatics analysis

Liu¹,

Wang²,

Wan³

et al. 2022

J Gastrointest Oncol

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Background: This study sought to identify candidate biomarkers associated with gastric cancer (GC) prognosis based on an integrated bioinformatics analysis.Methods: First, the GSE54129 and GSE79973 data sets were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) identified between the 2 data sets were screened using the limma software package in R, and the intersection DEGs were obtained by a Venn analysis. Subsequently, gene clustering and a functional analysis were performed to explore the roles of the DEGs. The protein-protein interaction (PPI) network of the genes in clusters was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins. A survival analysis evaluated the associations between the candidate genes and the overall survival of GC patients. A drug-gene interaction analysis and an external data set analysis were conducted using The Cancer Genome Atlas-Stomach Adenocarcinoma (TCGA-STAD) data set to validate the prognostic genes.Results: We extracted 421 intersection DEGs from the 2 GEO data sets. There were 5 gene clusters, and the functional analysis revealed that they were mainly associated with the extracellular matrix-receptor interaction pathway. The PPI interaction analysis identified the top 36 hub genes. The survival analysis revealed that 7 upregulated genes [i.e., platelet-derived growth factor receptor beta (PDGFRB), angiopoietin 2 (ANGPT2), vascular endothelial growth factor C (VEGFC), collagen type IV alpha 2 chain (COL4A2), collagen type IV alpha 1 chain (COL4A1), thrombospondin 1 (THBS1), and fibronectin 1 (FN1)] were associated with the survival prognosis of GC patients. The 20 drug-gene interaction pairs among the 4 genes and 18 drugs were obtained. Finally, TCGA-STAD data set was used to validate the expression levels of COL4A1, PDGFRB, and FN1.Conclusions: We found that 7 upregulated genes (i.e., PDGFRB, ANGPT2, VEGFC, COL4A2, COL4A1, THBS1, and FN1) were promising markers of prognosis in GC patients.

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CD33+ Immature Myeloid Cells Critically Predict Recurrence in Advanced Gastric Cancer

Cited by 10 publications

References 59 publications

Effect of oteracil in combination with gimeracil on longterm survival and postoperative complications in elderly patients undergoing radical surgery for biliary tract cancer

Effect of oteracil in combination with gimeracil on longterm survival and postoperative complications in elderly patients undergoing radical surgery for biliary tract cancer

Exhaustion profile on classical monocytes after LPS stimulation in patients with Crohn’s disease

Identification of candidate biomarkers associated with gastric cancer prognosis based on an integrated bioinformatics analysis

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