CD320 expression and apical membrane targeting in renal and intestinal epithelial cells

Chen, Yue; Gu, Xiabing; Zhang, Yikai; Zhang, Xianrui; Zhang, Ce; Li, Meng; Sun, Shujun; Dong, Ningzheng; Wu, Qingyu

doi:10.1016/j.ijbiomac.2021.12.158

Cited by 4 publications

(4 citation statements)

References 47 publications

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“…The N-terminal extracellular region of CD320 contains two LDLR domains, the second of which has a DSSDE motif (Figure 2). In polarized renal and intestinal epithelial cells, the DSSDE motif is required for specific apical trafficking of CD320 [51,57]. These findings indicate that the DSSDE motif in LDLR repeats may have a general role in apical trafficking in polarized epithelial cells.…”

Section: Regulation Of Sodium Homeostasis In Non-cardiac Tissuesmentioning

confidence: 78%

“…Further studies will be important to define the Rab11a-mediated mechanism, and to examine whether the DSSDE motif in other LDLR-containing proteins has a similar role in apical trafficking in polarized epithelial cells. Additional studies have shown that the DSSDE motif-dependent apical trafficking o corin and CD320 is mediated by Rab11a [51,57], a member of the small GTPase superfam ily, which plays a central role in apical trafficking in polarized epithelial cells [58] (Figure 2). Inhibition of Rab11a expression by a dominant negative Rab11a mutant or RAB11A gene knockdown abolished the specific apical targeting of corin and CD320 in MDCK and colon-derived Caco-2 cells [51,57].…”

Section: Regulation Of Sodium Homeostasis In Non-cardiac Tissuesmentioning

confidence: 99%

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Corin: A Key Mediator in Sodium Homeostasis, Vascular Remodeling, and Heart Failure

Zhang

et al. 2022

Biology

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Atrial natriuretic peptide (ANP) is a crucial element of the cardiac endocrine function that promotes natriuresis, diuresis, and vasodilation, thereby protecting normal blood pressure and cardiac function. Corin is a type II transmembrane serine protease that is highly expressed in the heart, where it converts the ANP precursor to mature ANP. Corin deficiency prevents ANP activation and causes hypertension and heart disease. In addition to the heart, corin is expressed in other tissues, including those of the kidney, skin, and uterus, where corin-mediated ANP production and signaling act locally to promote sodium excretion and vascular remodeling. These results indicate that corin and ANP function in many tissues via endocrine and autocrine mechanisms. In heart failure patients, impaired natriuretic peptide processing is a common pathological mechanism that contributes to sodium and body fluid retention. In this review, we discuss most recent findings regarding the role of corin in non-cardiac tissues, including the kidney and skin, in regulating sodium homeostasis and body fluid excretion. Moreover, we describe the molecular mechanisms underlying corin and ANP function in supporting orderly cellular events in uterine spiral artery remodeling. Finally, we assess the potential of corin-based approaches to enhance natriuretic peptide production and activity as a treatment of heart failure.

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Section: Regulation Of Sodium Homeostasis In Non-cardiac Tissuesmentioning

confidence: 78%

Section: Regulation Of Sodium Homeostasis In Non-cardiac Tissuesmentioning

confidence: 99%

Corin: A Key Mediator in Sodium Homeostasis, Vascular Remodeling, and Heart Failure

Zhang

et al. 2022

Biology

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“…Another, rather small fraction of Cbl is not absorbed at all, affecting microbiota metabolism and pathogenicity in large intestines. An even smaller amount is eliminated by the stool [15,16].…”

Section: Fate Of Cbl In the Gastrointestinal Tracktmentioning

confidence: 99%

“…Apart from this, cells also exhibit a remarkable intracellular TCN2, and apical CD320 expression in murine experiments. Thus excreted TCN2 can form HoloTC taken up by their receptors at the luminal surface of epithelial cells [16,17]. mediated endocytosis.…”

Section: Intracellular Fate Transport In Blood and Storagementioning

confidence: 99%

Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency Detected by Newborn Screening

et al. 2022

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Acquired vitamin B12 (vB12) deficiency (vB12D) of newborns is relatively frequent as compared with the incidence of inherited diseases included in newborn screening (NBS) of different countries across the globe. Infants may present signs of vB12D before 6 months of age with anemia and/or neurologic symptoms when not diagnosed in asymptomatic state. The possibility of identifying vitamin deficient mothers after their pregnancy during the breastfeeding period could be an additional benefit of the newborn screening. Vitamin supplementation is widely available and easy to administer. However, in many laboratories, vB12D is not included in the national screening program. Optimized screening requires either second-tier testing or analysis of new urine and blood samples combined with multiple clinical and laboratory follow ups. Our scope was to review the physiologic fate of vB12 and the pathobiochemical consequences of vB12D in the human body. Particular emphasis was put on the latest approaches for diagnosis and treatment of vB12D in NBS.

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P34L Mutation of swine TIM-1 enhances its ability to mediate Japanese encephalitis virus infection

Jiao

Xie

Liang

et al. 2022

Veterinary Microbiology

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CD320 expression and apical membrane targeting in renal and intestinal epithelial cells

Cited by 4 publications

References 47 publications

Corin: A Key Mediator in Sodium Homeostasis, Vascular Remodeling, and Heart Failure

Corin: A Key Mediator in Sodium Homeostasis, Vascular Remodeling, and Heart Failure

Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency Detected by Newborn Screening

P34L Mutation of swine TIM-1 enhances its ability to mediate Japanese encephalitis virus infection

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