CD31 (JC70) expression in plasma cells: an immunohistochemical analysis of reactive and neoplastic plasma cells.

Govender, Dhirendra; Harilal, P; Dada, M A; Chetty, Runjan

doi:10.1136/jcp.50.6.490

Cited by 38 publications

(23 citation statements)

References 18 publications

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“…CD31 was also positive in staining the CD138 immunoreactive plasma cells, but CD34 and Factor VIII were negative. Positive immunohistochemical staining for CD31 has previously been reported in reactive extramedullar plasma cells [4]. This was demonstrated in the present study in the plasma cell rich granulation tissue ( fig.…”

Section: Discussionsupporting

confidence: 74%

“…Bronchoscopy and cytological examinations are often negative. Percutaneous needle biopsy may induce a diagnostic dilemma because of the difficulty to differentiate inflammatory pseudotumour from fibrohistiocytic neoplasms, nodular sclerosing Hodgkin's lymphoma, primary lung cancer and especially fibrosing mediastinitis [4]. In addition, due to the specific unilateral localisation of the lesion in the present case, fibrosing mediastinitis is less probable.…”

Section: Discussionmentioning

confidence: 69%

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A 61-year-old female patient with right-sided pleuritic chest pain and fatigue

Messaoudi¹,

Cocker²,

Eynden³

et al. 2009

European Respiratory Journal

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A 61-yr-old Caucasian female patient was investigated because of right-sided pleuritic chest pain. The patient had a 2-month history of chronic, nonproductive cough, extreme fatigue, night sweats and reduced exercise tolerance. Initially, the patient was treated with antibiotics for presumed pneumonia. She had smoked for .20 pack-yrs and her medical history included parotidectomy for Warthin tumour, resection of a benign cyst in the left breast and varicectomy.Physical examination showed no clinical signs of respiratory distress. Sinus rhythm was present with a heart rate of 88 bpm and blood pressure of 135/80 mmHg. Cardiopulmonary auscultation revealed no significant abnormalities and there was no hepatomegaly or limb oedema. No lymphadenopathy was found in the neck, supraclavicular, axillary or inguinal regions.The laboratory results showed an elevated C-reactive protein of 5.02 mg?dL -1. Low haemoglobin and haematocrit values were in keeping with anaemia. Studies of coagulability were all within normal ranges. Arterial blood gas analysis while breathing ambient air showed an arterial oxygen tension of 66 mm Hg, carbon dioxide arterial tension of 40 mmHg, pH of 7.43 and arterial oxygen saturation of 94%. Pulmonary function tests revealed a mild restrictive defect with a reduced diffusing capacity.A chest radiograph ( fig. 1) and computed tomography (CT) scans (figs 2 and 3) were performed and the patient underwent bronchoscopy and mediastinoscopy. Bronchoscopy revealed no endobronchial involvement. Subsequent biopsies were all found to be negative.All accessible lymph nodes in the superior mediastinum and the region of the right mainstem bronchus were biopsied by cervical mediastinoscopy. Extensive unilateral mediastinal fibrosis was present around the right pulmonary artery and mainstem bronchus.Subsequently, the patient underwent thoracoscopy to obtain a more precise diagnosis. However, extensive inflammation and multiple dense adhesions rendered appropriate investigation impossible, even after opening of the pericardium. Conversion to a limited thoracotomy was performed. Operative findings were general hepatisation of the right lung and nodular lesions in the right lower lobe, which were resected by wedge excision. Central biopsies were also taken.Despite these investigations, a final diagnosis could not be obtained. As the right lung was afunctional, an intrapericardial pneumonectomy was performed and definitive pathological examination revealed the final diagnosis (figs 4 and 5).

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 69%

A 61-year-old female patient with right-sided pleuritic chest pain and fatigue

Messaoudi¹,

Cocker²,

Eynden³

et al. 2009

European Respiratory Journal

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“…It is sensitive and much more specific than CD34. However, it has been reported to react with plasma cells, 138 macrophages, 139 and some carcinomas and mesotheliomas 140 . Fli‐1, a new marker for PNET, is also a good marker for vascular tumours with a good sensitivity 84 .…”

Section: Sarcomas For Which Ihc Is Determinant For the Diagnosismentioning

confidence: 99%

Immunohistochemistry in the diagnosis of soft tissue tumours

Coindre

2003

Histopathology

105

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Immunohistochemistry is particularly important in the field of soft tissue tumours because of their variety and the frequent difficulty of diagnosis. The first part of this paper discusses useful or new antibodies, together with others that are no longer of use. The second part is devoted to the role of immunohistochemistry in the diagnosis of soft tissue tumours: identification of some rare or atypical benign lesions, identification of non-mesenchymal malignant tumours, and classification of sarcomas. The respective roles of immunohistochemistry and molecular biology are underlined.

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“…Previous studies have suggested that PECAM-1 may be expressed on CD19-positive B cells derived from bone marrow (17), reactive plasma cells defined by CD38…”

mentioning

confidence: 99%

Src Homology 2 Domain-Containing Protein-Tyrosine Phosphatases, SHP-1 and SHP-2, Are Required for Platelet Endothelial Cell Adhesion Molecule-1/CD31-Mediated Inhibitory Signaling

Henshall

Jones

Wilkinson

et al. 2001

The Journal of Immunology

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Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is a newly assigned member of the Ig immunoreceptor tyrosine-based inhibitory motif superfamily, and its functional role is suggested to be an inhibitory receptor that modulates immunoreceptor tyrosine-based activation motif-dependent signaling cascades. To test whether PECAM-1 is capable of delivering inhibitory signals in B cells and the functional requirement of protein-tyrosine phosphatases (PTPs) for this inhibitory signaling, we generated chimeric FcγRIIB1-PECAM-1 receptors containing the extracellular and transmembrane portions of murine FcγRIIB1 and the cytoplasmic domain of human PECAM-1. These chimeric receptors were stably expressed in chicken DT40 B cells either as wild-type or mutant cells deficient in SHP-1−/−, SHP-2−/−, SHIP−/−, or SHP-1/2−/− and then assessed for their ability to inhibit B cell Ag receptor (BCR) signaling. Coligation of wild-type FcγRIIB1-PECAM-1 with BCR resulted in inhibition of intracellular calcium release, suggesting that the cytoplasmic domain of PECAM-1 is capable of delivering an inhibitory signal that blocks BCR-mediated activation. This PECAM-1-mediated inhibitory signaling correlated with tyrosine phosphorylation of the FcγRIIB1-PECAM-1 chimera, recruitment of SHP-1 and SHP-2 PTPs by the phosphorylated chimera, and attenuation of calcium mobilization responses. Mutational analysis of the two tyrosine residues, 663 and 686, constituting the immunoreceptor tyrosine-based inhibitory motifs in PECAM-1 revealed that both tyrosine residues play a crucial role in the inhibitory signal. Functional analysis of various PTP-deficient DT40 B cell lines stably expressing wild-type chimeric FcγRIIB1-PECAM-1 receptor indicated that cytoplasmic Src homology 2-domain-containing phosphatases, SHP-1 and SHP-2, were both necessary and sufficient to deliver inhibitory negative regulation upon coligation of BCR complex with inhibitory receptor.

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CD31 (JC70) expression in plasma cells: an immunohistochemical analysis of reactive and neoplastic plasma cells.

Abstract: Aims-To investigate the immunohisto-

Cited by 38 publications

References 18 publications

A 61-year-old female patient with right-sided pleuritic chest pain and fatigue

A 61-year-old female patient with right-sided pleuritic chest pain and fatigue

Immunohistochemistry in the diagnosis of soft tissue tumours

Src Homology 2 Domain-Containing Protein-Tyrosine Phosphatases, SHP-1 and SHP-2, Are Required for Platelet Endothelial Cell Adhesion Molecule-1/CD31-Mediated Inhibitory Signaling

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