CD30+ Transformed Mycosis Fungoides Associated with Sweet-like Dermatosis

André, Florine; Prins, Christa; Gillet, M; Guenova, Emmanuella; Blanchard, Gabriela

doi:10.2340/actadv.v102.1170

Cited by 1 publication

(4 citation statements)

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“…CD30 (Ki‐1) is a cell surface protein receptor and is usually detected on activated B and T‐cells 20 . The cytoplasmic/membrane expression of CD30 on lymphocytes may indicate a lymphoproliferative disorder such as lymphomatoid papulosis, 21 or anaplastic large cell lymphoma, 22 advanced mycosis fungoides, or borderline cases (collectively known as CD30+ lymphoproliferative disorders) 22,23 . Rarely, Hodgkin disease, which is also characterized by CD30 expression in large cells, has been reported to secondarily involve the skin and may be considered in the differential 24 .…”

Section: Discussionmentioning

confidence: 99%

“…One study has investigated the CD30 expression in neutrophil‐rich inflammatory skin disorders and the expression was seen in large atypical cells that were lymphoid in origin and mostly T‐cells, 2 which is not surprising, given the normal expression of the marker on activated T and B‐cells. Few other cases of neutrophilic dermatosis with CD30+ large cells are reported in association with transformed mycosis fungoides 23,29 . Only one case of Sweet neutrophilic dermatosis with large lymphocytes expressing CD30 (a small subset of the infiltrate) An additional case of drug‐induced (Bortezomib) Sweet syndrome also reported to harbor CD30+ large cells 30 .…”

Section: Discussionmentioning

confidence: 99%

“…20 The cytoplasmic/membrane expression of CD30 on lymphocytes may indicate a lymphoproliferative disorder such as lymphomatoid papulosis, 21 or anaplastic large cell lymphoma, 22 advanced mycosis fungoides, or borderline cases (collectively known as CD30+ lymphoproliferative disorders). 22,23 Rarely, Hodgkin disease, which is also characterized by CD30 expression in large cells, has been reported to secondarily involve the skin and may be considered in the differential. 24 solid organ and germ cell malignancies, 1 systemic mastocytosis, 25 viral or drug eruption, 26 and arthropod assault (including nodular scabies).…”

Section: Case Reportmentioning

confidence: 99%

“…Few other cases of neutrophilic dermatosis with CD30+ large cells are reported in association with transformed mycosis fungoides. 23,29 Only one case of Sweet neutrophilic dermatosis with large lymphocytes expressing CD30 (a small subset of the infiltrate) An additional case of drug-induced (Bortezomib) Sweet syndrome also reported to harbor CD30+ large cells. 30 In cases of CD30 expression in inflammatory and non-lymphoid neoplastic disorders, the CD30+ cells have been lymphocytes.…”

Section: Case Reportmentioning

confidence: 99%

See 3 more Smart Citations

Neoplastic or inflammatory? A case report of Sweet syndrome with CD30+ cells in a patient with B‐lymphoblastic leukemia

Ehyaee,

Reddy,

Ahmed

2023

J Cutan Pathol

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CD30+ cells are typically part of lymphoproliferative disorders but can also be seen in inflammatory dermatoses. We present a case of 47‐year‐old man with a history of B‐lymphoblastic leukemia (B‐ALL) who presented with fever, leukocytosis, and papulonodular skin lesions, involving the extremities and trunk. A punch biopsy specimen demonstrated papillary dermal edema with a neutrophilic and histiocytic infiltrate extending into the subcutis. The infiltrate also harbored scattered large cells that were positive for CD30 and demonstrated the immunohistochemical profile of monocytes. A diagnosis of histiocytoid Sweet syndrome with CD30+ cells was made. The case is unique, demonstrating a combination of Sweet syndrome variants with subcutis involvement, histiocytoid morphology, and large CD30+ cells. A prior history of B‐ALL and immunohistochemical profile of monocytes with immature morphology broadened the differential diagnosis and added to the diagnostic challenge.

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