CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer

Lam, Jian Hang; Hong, Michelle; Koo, Si-Lin; Chua, Clarinda; Lim, Kah Ling; Wee, Felicia; Wan, Wei Keat; Leow, Wei Qiang; Yeo, Joo Guan; Tan, Iain Bee Huat; Yeong, Joe Poh Sheng; Lim, Tony Kiat Hon; Lim, Tong Seng

doi:10.1007/s00262-021-02859-x

Cited by 15 publications

(13 citation statements)

References 61 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the increase of regulatory T cell levels in liver metastatic cancer tissues inhibited the infiltration of immune cells into the tumor tissue, which promoted the growth and metastasis of tumor cells, and ultimately led to the poor prognosis of patients. The role of regulatory T cells has also been confirmed in the studies of other malignant tumors, further supporting the findings of the present study (15)(16)(17)(18)(19)(20).…”

Section: Discussionsupporting

confidence: 91%

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis

Wang¹,

Tang²,

Ouyang³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

Background: Liver metastasis is common in colorectal cancer patients. Immunotherapy covers a wide range of tumor types and is safer than traditional radiotherapy and chemotherapy. However, its overall effective rate is only 20-40%. At present, there is a lack of relevant research clarifying whether the changes and clinical significance of the immune microenvironment in colorectal cancer patients with liver metastasis are conducive to enhancing the promotion and further improving the efficacy of immunotherapy. Methods:We retrospectively collected the data of 50 colorectal cancer patients with liver metastasis treated in Chongqing University Cancer Hospital from January 2017 to January 2019. Liver metastatic cancer tissues and normal liver tissues were collected to detect the levels of immune cells in the two samples. At the same time, the correlation between T-cell subsets in the liver metastatic cancer tissue immune microenvironments of colorectal cancer patients and prognosis was analyzed.Results: Compared with the normal liver tissues, the level of T helper cell 1/T helper cell 2 (Th1/Th2) in the liver metastatic cancer tissues was significantly decreased (0.88±0.24 vs. 1.34±0.27, P=0.000), while the levels of regulatory T cells were markedly increased (8.57±2.31 vs. 6.89±1.71, P=0.000). The Th1/Th2 level in liver metastatic cancer tissue exhibited a good predictive value for recurrence and survival 3 years after surgery, and the areas under the curves were 0.783 (95% confidence interval: 0.649-0.916, P=0.002) and 0.763 (95% confidence interval: 0.628-0.898, P=0.001), respectively. Moreover, the regulatory T-cell level in liver metastatic cancer tissue had a good predictive value for recurrence and survival at 3 years postoperatively, and the areas under the curves were 0.788 (95% confidence interval: 0.656-0.919, P=0.002) and 0.763 (95% confidence interval: 0.628-0.897, P=0.001), respectively. Conclusions:The immunosuppressive condition of liver metastasis in colorectal cancer patients was related to poor prognosis.

show abstract

Section: Discussionsupporting

confidence: 91%

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis

Wang¹,

Tang²,

Ouyang³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

show abstract

“…Lam JH et al. have found that a high density of tumor‐infiltrating CD30 + OX40 + Tregs (Figure 1) in CRCs patients is associated with improved prognosis, which may act as a diagnostic and prognostic biomarker in CRCs 93 …”

Section: Treg Subsets In Tumor Immunitymentioning

confidence: 99%

Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity

Jiang

Zhu

Wang

et al. 2022

MedComm

View full text Add to dashboard Cite

CD4 + CD25 + regulatory T cells (Tregs), a subpopulation of naturally CD4 + T cells that characteristically express transcription factor Forkhead box P3 (FOXP3), play a pivotal role in the maintenance of immune homeostasis and the prevention of autoimmunity. With the development of biological technology, the understanding of plasticity and stability of Tregs has been further developed. Recent studies have suggested that human Tregs are functionally and phenotypically diverse. The functions and mechanisms of different phenotypes of Tregs in different disease settings, such as tumor microenvironment, autoimmune diseases, and transplantation, have gradually become hot spots of immunology research that arouse extensive attention. Among the complex functions, CD4 + CD25 + FOXP3 + Tregs possess a potent immunosuppressive capacity and can produce various cytokines, such as IL‐2, IL‐10, and TGF‐β, to regulate immune homeostasis. They can alleviate the progression of diseases by resisting inflammatory immune responses, whereas promoting the poor prognosis of diseases by helping cells evade immune surveillance or suppressing effector T cells activity. Therefore, methods for targeting Tregs to regulate their functions in the immune microenvironment, such as depleting them to strengthen tumor immunity or expanding them to treat immunological diseases, need to be developed. Here, we discuss that different subpopulations of Tregs are essential for the development of immunotherapeutic strategies involving Tregs in human diseases.

show abstract

“…Taking advantage of single cell-RNA (scRNA) sequencing, it has been shown that tumor-infiltrating Tregs express high levels of IL-1R2 compared to other lymphocytes, in particular in breast, colorectal or non-small-cell lung cancers ( 50 , 51 ). Conversely, low percentage of IL-1R2 + Treg cells was reported among circulating CD45RO + lymphocytes from colorectal cancer patients ( 52 ). IL-1R2 + Treg clonality was investigated by combining scRNA-sequencing with TCR sequencing in an experimental model of skin graft, mimicking human papillomavirus (HPV)–associated epithelial hyperplasia ( 53 ).…”

Section: The Decoy Receptor Il-1r2mentioning

confidence: 99%

Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease

et al. 2022

View full text Add to dashboard Cite

Interleukin-1 (IL-1) is a primary cytokine of innate immunity and inflammation. IL-1 belongs to a complex family including ligands with agonist activity, receptor antagonists, and an anti-inflammatory cytokine. The receptors for these ligands, the IL-1 Receptor (IL-1R) family, include signaling receptor complexes, decoy receptors, and negative regulators. Agonists and regulatory molecules co-evolved, suggesting the evolutionary relevance of a tight control of inflammatory responses, which ensures a balance between amplification of innate immunity and uncontrolled inflammation. IL-1 family members interact with innate immunity cells promoting innate immunity, as well as with innate and adaptive lymphoid cells, contributing to their differentiation and functional polarization and plasticity. Here we will review the properties of two key regulatory receptors of the IL-1 system, IL-1R2, the first decoy receptor identified, and IL-1R8, a pleiotropic regulator of different IL-1 family members and co-receptor for IL-37, the anti-inflammatory member of the IL-1 family. Their complex impact in pathology, ranging from infections and inflammatory responses, to cancer and neurologic disorders, as well as clinical implications and potential therapeutic exploitation will be presented.

show abstract

CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer

Cited by 15 publications

References 61 publications

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis

Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity

Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease

Contact Info

Product

Resources

About