CD30 Ligand/CD30 Interaction Is Involved in Pathogenesis of Inflammatory Bowel Disease

Somada, Shinichi; Matsubara, Hiromi; Nakamura, Kazuhiko; Sun, Xun; Honda, Kazuo; Ihara, Eikichi; Akiho, Hirotada; Takayanagi, Ryoichi; Yoshikai, Yasunobu; Podack, Eckhard R.; Tani, Kenzaburo

doi:10.1007/s10620-012-2129-0

Cited by 11 publications

(6 citation statements)

References 20 publications

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“…Recently, the interaction of CD30/CD30L was reported to play some role in the crosstalk between natural killer and dendritic cells, and is critical for humoral immunity (26,27). Meanwhile, some studies demonstrate that CD30L/CD30 might be useful as a novel biological therapy for allergic rhinitis, inflammatory bowel disease, autoimmune diabetes, and chronic inflammatory skin diseases like psoriasis or atopic dermatitis (28)(29)(30)(31). However, there is no report about whether there is some role of CD30L in liver injury.…”

Section: Discussionmentioning

confidence: 99%

Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L.

Sheng

Deng

et al. 2014

BST

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Section: Discussionmentioning

confidence: 99%

Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L.

Sheng

Deng

et al. 2014

BST

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“…6 Accordingly, elevated levels of sCD30 have been found in various Th2-dominated diseases, such as atopic dermatitis, 42 hymenoptera venom allergy, 43 and Graves disease. 44 However, increase in expression and release of sCD30 have also been found in Th1-dominated diseases, such as colitis ulcerosa, 45 and granulomatosis with polyangiitis. 46 The current paradigm is that sCD30 levels in immunologic diseases reflect the activation Abbreviations: AID, activation-induced cytidine deaminase; DC, dendritic cell; NK, natural killer.…”

Section: Expression Of Cd30 and Scd30 In Allergic And Immunologic Dis...mentioning

confidence: 99%

CD30 in Systemic Mastocytosis

Anrooij¹,

Kluin²,

Elberink³

et al. 2014

Immunology and Allergy Clinics of North America

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“…CD30L/CD30 pathway acts as an accelerator of enteritis in a murine disease model. CD30-Ig may be a therapeutic tool to block [45]. …”

Section: Cd30 In Colitis In Animal Models and Manmentioning

confidence: 99%

CD30: from basic research to cancer therapy

Matsubara

Podack

2013

Immunol Res

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The FDA recently approved an agonistic anti-CD30 drug conjugate, Brentuximab vedotin, for the treatment for CD30-positive lymphomas. The potent clinical activity of Brentuximab vedotin in Hodgkin’s lymphoma and anaplastic large-cell lymphoma was greeted with great enthusiasm by oncologists as it provided a new treatment modality for these diseases. In this review, we will describe how we obtained the hybridoma by pursuing a basic research experiment unrelated to CD30. I will also review what we know about the normal biological functions of CD30 that were studied primarily in murine models of disease but also in patients. The picture emerging is that one of the primary functions of CD30 is the control of memory cells providing costimulation and trafficking information or inducing apoptosis in a microenvironment and cytokine milieu-dependent manner.

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CD30 Ligand/CD30 Interaction Is Involved in Pathogenesis of Inflammatory Bowel Disease

Cited by 11 publications

References 20 publications

Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L.

Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L.

CD30 in Systemic Mastocytosis

CD30: from basic research to cancer therapy

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