CD30+ Cutaneous Lymphoma in Association With Atopic Eczema

Fletcher, C L; Orchard, Guy; Hubbard, V. G.; Whittaker, Sean; Edelson, Richard L.; Russell‐Jones, Robin

doi:10.1001/archderm.140.4.449

Cited by 49 publications

(47 citation statements)

References 21 publications

(14 reference statements)

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“…Nevertheless, what is uncommon in the case reports [2, 4], and in our case, is the young age at the onset of the lymphoma and the rapidly aggressive course of the disease.…”

Section: Discussionmentioning

confidence: 52%

“…Three cases of patients with AD developing cutaneous CD30+ lymphoma have already been reported [2]. They developed primary cutaneous anaplastic large cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…None of them had received immunosuppresive oral treatment. Two of them had a rapidly aggressive clinical course with nodal involvement, and 1 of them died [2]. Two cases of Sezary syndrome concerning a young man with severe AD have been published [8, 9].…”

Section: Discussionmentioning

confidence: 99%

“…CsA was initiated in a 25- [2] and a 39-year-old [3] patient. They developed a type A lymphomatoid papulosis and a CD30+ large cell lymphoma, respectively, and both cases improved after interruption of CsA.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge only 2 previous cases of CD30+ cutaneous lymphoma have been reported in patients treated for atopic dermatitis (AD) with CsA [2, 3]. Those 2 cases resolved after interruption of CsA therapy.…”

Section: Introductionmentioning

confidence: 99%

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Aggressive CD30 Large Cell Lymphoma after Cyclosporine Given for Putative Atopic Dermatitis

et al. 2006

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Atopic dermatitis (AD) is not regarded as a predisposing condition for cutaneous T cell lymphoma. Cyclosporine (CsA) is an efficient therapy in AD, and its side effects, including lymphocytic proliferation, are rare at the low dose used in such cases. So far 3 cases of patients who developed cutaneous T cell lymphoma under CsA treatment for atopy have been described. An adult patient with a history of AD received CsA therapy because of an atypical flare-up of his eruption. He rapidly developed papular atypical lesions, then followed by the onset of a voluminous cutaneous tumor leading to the diagnosis of mycosis fungoides (MF) transformed in CD30+ large cell lymphoma with nodal and blood involvement. No improvement occurred after withdrawing of CsA, and he required a polychemotherapy and an allograft. This case illustrates the dramatic evolution of an MF under CsA given in the hypothesis of AD. It stresses the fact that skin biopsies should be taken in case of atypical AD to rule out MF and avoid such an aggressive evolution under immunosuppressive therapy.

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“…Nevertheless, what is uncommon in the case reports [2, 4], and in our case, is the young age at the onset of the lymphoma and the rapidly aggressive course of the disease.…”

Section: Discussionmentioning

confidence: 52%

“…Three cases of patients with AD developing cutaneous CD30+ lymphoma have already been reported [2]. They developed primary cutaneous anaplastic large cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aggressive CD30 Large Cell Lymphoma after Cyclosporine Given for Putative Atopic Dermatitis

et al. 2006

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Fatal Cytotoxic Cutaneous Lymphoma Presenting as Ulcerative Psoriasis

Weenig

Comfere²,

Gibson³

et al. 2009

Arch Dermatol

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Observations: We describe 3 men recently referred to our institution for evaluation and treatment of severe, ulcerative psoriasis that ultimately was determined to be aggressive, cytotoxic, cutaneous lymphoma. Each had a history of relatively indolent, nonulcerative patches and plaques (duration, 2-45 years) that changed to ulcerated lesions; these rapidly progressed and eventuated in death. Conclusions: The clinical characteristics of the skin lesions and the histopathologic findings form a distinct and rare presentation of cutaneous lymphoma. The initial course is similar to that of mycosis fungoides but eventuates in a highly aggressive disease with fatal outcome.

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Cutaneous Lymphomas

Whittaker,

Child

2016

Rook's Textbook of Dermatology, Ninth Edition

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Primary cutaneous lymphomas are extranodal non‐Hodgkin lymphomas and consist of different variants defined by specific clinicopathological and immunophenotypic features. Primary cutaneous T‐cell lymphomas are the most common subset and are derived from resident memory T cells, whereas primary cutaneous B‐cell lymphomas are more closely related to their nodal counterparts with derivation from B cells at different stages of differentiation. Whilst the underlying pathogenesis of cutaneous lymphomas remains unclear, there is emerging evidence for a heterogenous pattern of somatic mutations and epigenetic events. Although the prognosis for many indolent primary cutaneous lymphoma variants remains excellent, the treatment of some rare variants and advanced stages of mycosis fungoides and Sezary syndrome represents an unmet medical need in view of high levels of chemotherapy resistance and limited durable responses. A variety of novel biological agents have been recently approved but long‐term remissions are rare. There is still an urgent need to clarify the underlying molecular pathogenesis and identify more effective targeted therapies for mycosis fungoides and Sézary syndrome.

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CD30+ Cutaneous Lymphoma in Association With Atopic Eczema

Cited by 49 publications

References 21 publications

Aggressive CD30 Large Cell Lymphoma after Cyclosporine Given for Putative Atopic Dermatitis

Aggressive CD30 Large Cell Lymphoma after Cyclosporine Given for Putative Atopic Dermatitis

Fatal Cytotoxic Cutaneous Lymphoma Presenting as Ulcerative Psoriasis

Cutaneous Lymphomas

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