CD2AP is Co-Expressed with Tropomyosin-Related Kinase A and Ras-Related Protein Rab-5A in Cholinergic Neurons of the Murine Basal Forebrain
Lindsey Avery Fitzsimons,
Mohammad Atif-Sheikh,
Jayden Lovely
et al.
Abstract:Basal forebrain cholinergic neurons project to the hippocampus and cortex, are critical for learning and memory, and are central to the pathogenesis of Alzheimer's disease (AD). GWAS have consistently shown that genomic variants at the CD2AP gene locus are associated with significant increased risk of AD. GWAS studies have also shown that genetic variants in endocytosis genes, including RAB5A, significantly increase susceptibility to AD. Previous work in our lab has shown that CD2AP functions as a docking-scaf… Show more
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