CD28 gene polymorphisms and acute cellular rejection after liver transplantation

Thude, Hansjörg; Tiede, Petra; Sterneck, Martina; Peine, Sven; Nashan, Björn; Koch, Martina

doi:10.1016/j.humimm.2020.10.002

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Biomarkers For Prediction and Monitoring Of Rejection1

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2022

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“…At postoperative days 7–13, Minguela et al [42] showed significant elevations in CD28+ T cells in patients who went on to develop ACR. CD28 + is responsible for binding to APCs, triggering release of IL-2 and generating an immune response [43 ▪ ].…”

Section: Biomarkers For Prediction and Monitoring Of Rejectionmentioning

confidence: 99%

Biomarkers of rejection in liver transplantation

Perottino

Harrington

Levitsky

2022

Current Opinion in Organ Transplantation

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Purpose of reviewLiver transplantation is a lifesaving therapy for thousands of individuals with end-stage liver disease across the world. Allograft rejection, which is traditionally detected through an invasive graft biopsy, is a major complication for liver transplant recipients in the postoperative period. Biomarkers represent a relatively newer and safer means of detecting and predicting transplant rejection when compared with the current standard of care: liver biopsy. This review serves to compile recent progress in the field of biomarker discovery in liver allograft rejection. Recent findingsSeveral promising biomarkers exist in the field of liver transplant rejection. Recent developments include blood genomic assays measuring miRNA, mRNA and donor-derived cell-free DNA. Additionally, serum levels of cytokines, proteoforms, donor-specific antibodies and immunophenotyping have shown promising results in predicting rejection pre and/or posttransplant.

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Section: Biomarkers For Prediction and Monitoring Of Rejectionmentioning

confidence: 99%