CD24-associated ceRNA network reveals prognostic biomarkers in breast carcinoma

Abstract

Breast cancer is one of the most common cancer types which is described as the leading cause of cancer death in women. After competitive endogenous RNA (ceRNA) hypothesis was proposed, this triple regulatory network has been observed in various cancers, and increasing evidences reveal that ceRNA network plays a significant role in the migration, invasion, proliferation of cancer cells. In the current study, our target is to construct a CD24-associated ceRNA network, and to further identify key prognostic biomarkers in breast cancer. Using the transcriptom profiles from TCGA database, we performed a comprehensive analysis between CD24high tumor samples and CD24low tumor samples, and identified 132 DElncRNAs, 602 DEmRNAs and 26 DEmiRNAs. Through comprehensive analysis, RP1-228H13.5/miR-135a-5p/BEND3 and SIM2 were identified as key CD24-associated biomarkers, which exhibited highly significance with overall survival, immune microenvironment as well as clinical features. To sum up the above, the current study constructed a CD24-associated ceRNA network, and RP1-228H13.5/miR-135a-5p/BEND3 and SIM2 axis worked as a potential therapeutic target and a predictor for BRCA diagnosis and prognosis.

rGO nickel matrix composites with high ozone degradation efficiency under high humidity

“…According to the study on the mechanism of ozone decomposition on NiCH, 44 the green divalent nickel material is converted to a black trivalent nickel material after the reaction. We achieved self-reduction of the catalyst by exposing the reacted catalyst to the air, and the corresponding catalyst was converted from black to green (Ni 3+ -Ni 2+ ).…”