CD226 deficiency improves cognitive functions and ameliorates anxiety‐like behaviors in mice

Abstract

BackgroundCD226 is a cell surface adhesion molecule expressed in the immune system and central nervous system. Although the role of CD226 in the function of immune cells has been well studied, there has been no report on the potential functional significance of CD226 in neural cells.MethodsWe investigated the role of CD226 on the cognitive function and behaviors using CD226 knockout (CD226KO) and wild‐type mice. The spatial learning and memory were characterized using Morris water maze test, and the behaviors were evaluated using open field and elevated plus maze tests. IL‐10 expression in the hippocampus was measured using RT‐PCR and ELISA.ResultsThe results showed that CD226KO mice displayed increased spatial learning and memory than the wild‐type controls. We also found that genetic deletion of CD226 resulted in decreased anxiety‐like behaviors. In addition, the hippocampal expression level of IL‐10 was increased in the CD226KO mice compared with the WT mice.ConclusionsOur findings suggest that CD226 plays an important role in the modulation of cognition and anxiety in mice.

Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease

“…Indeed, IL-10 or CD-155 loaded exosomes may enhance the co-inhibitory receptor TIGIT, lowering microglial intracellular iron. In addition, the CD226 genetic variant, Gly307Ser, was associated with several autoimmune disorders, suggesting that CD 226 inhibition may facilitate tolerized immunity and benefit the treatment of these conditions as well (201, 202).…”