CD21 antigen in T‐lineage neoplastic lymphoid cells: Characteristic expression at thymic stage

Tatsumi, E; Yoneda, Noriko; Yamaguchi, Nobuo

doi:10.1002/ajh.2830450211

Cited by 9 publications

(9 citation statements)

References 22 publications

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“…However, earlier studies showed that T‐acute lymphoblastic leukemia (ALL) cell line (MOLT4), null cells, and undifferentiated T‐cells also expressed functional C3d‐receptors and are able to bind to EBV 42,43 . In addition, Tatsumi et al 44 . detected expression of CD21, which corresponds to the C3d component of EBV receptor, in 80% (8/10) of thymic stage T‐cell ALL/lymphoblastic lymphoma (LBL), but not in pro‐ or early thymic T‐ALL/LBL.…”

Section: Discussionmentioning

confidence: 99%

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Pattern of Epstein–Barr virus association in childhood non‐Hodgkin's lymphoma: Experience of University of Malaya Medical Center

Peh¹,

Nadarajah²,

Tai³

et al. 2004

Pathology International

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The pattern of childhood non-Hodgkin's lymphoma (NHL) usually differs in adults. The most common subtypes are lymphoblastic, Burkitt's and anaplastic large cell lymphoma. Recent data indicate that a higher risk of developing lymphoma is associated in children of certain ethnic origins. The difference is probably related to the underlying etiological factors of these diseases, and Epstein-Barr virus (EBV) is a strong candidate. The present study aims to determine the disease pattern of childhood lymphomas in the University Hospital Kuala Lumpur, for a direct comparison to the reported data of adults from the same medical center. A total of 69 and 34 childhood NHL and Hodgkin's lymphomas, respectively, were retrieved. The most common subtypes were lymphoblastic (23 cases), Burkitt's (25 cases) and anaplastic large cell lymphomas (9 cases). Epstein-Barr virus association was more prevalent in B-cell (23%) than T-cell (12%) lymphomas. The most common EBV-associated tumor was Burkitt's lymphoma, and there was an increased risk of EBV association for Burkitt's lymphoma in Chinese patients. In conclusion, the pattern of childhood lymphoma in Malaysia is relatively similar to children elsewhere in the world. The EBV association of B- and T-NHL differs between children and adults from the same medical center because of differences in the subtype composition in these two age groups.

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Section: Discussionmentioning

confidence: 99%

“…42,43 In addition, Tatsumi et al . 44 detected expression of CD21, which corresponds to the C3d component of EBV receptor, in 80% (8/10) of thymic stage T-cell ALL/lymphoblastic lymphoma (LBL), but not in pro-or early thymic T-ALL/ LBL. Therefore, EBV may infect these cells by binding to the C3d component of the EBV receptor.…”

Section: Site Of Presentationmentioning

confidence: 99%

Pattern of Epstein–Barr virus association in childhood non‐Hodgkin's lymphoma: Experience of University of Malaya Medical Center

Peh¹,

Nadarajah²,

Tai³

et al. 2004

Pathology International

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“…17 Usually TdT is dominantly expressed in most immature hematopoetic cell stage, eg in pro T-cell / pro B-cell stage of maturation, 18,19 but some previous studies reported that in thymic stage (CD3-CD4-CD8, CD3-CD4+CD8+, CD3+CD4±CD8± lymphoblast) TdT was still almost always expressed. 16,17,20 Negative TdTs are more easily found in CD7+CD5-CD2-lymphoblast. 16,17,20 Our negative TdT cases might be from positive myeloid marker expressingblasts and the only one positive TdT case was negative myeloid marker expressing-blast.…”

Section: Discussionmentioning

confidence: 99%

“…16,17,20 Negative TdTs are more easily found in CD7+CD5-CD2-lymphoblast. 16,17,20 Our negative TdT cases might be from positive myeloid marker expressingblasts and the only one positive TdT case was negative myeloid marker expressing-blast. More samples are needed to get the similar conclusion as previously reported that TdT transcripts in myeloid marker + ALL is reduced than in myeloid marker -ALL.…”

Section: Discussionmentioning

confidence: 99%

T-lineage blast crisis of chronic myelogenous leukemia: simple record of 4 cases

Taroeno-Hariadi¹,

Tatsumi²,

Hardianti³

et al. 2005

Med J Indones

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Krisis blastik pada lekemia mielositik kronik (CML) bisa berasal dari lini granulosit, monosit, eritrosit, limfoid (sel B atau sel T), dan megakariositik. Krisis blastik seri limfoid biasanya berupa sel B dengan fenotipik sel Pre-B, di mana Ig permukaan belum diekspresikan. Krisis blastik dari sel T sangat jarang didapatkan. Tujuan penelitian : mendeskripsikan gambaran fenotipik, transkrip fusi bcr-abl, dan CD3 sitoplasmik, dan terminal deoxynucleotidyl transferase pada kasus-kasus CML dengan krisis blastik seri limfoid-T. Laporan kasus dari 4 kasus leukemia mielogenik kronik dengan krisis blastik sel-sel T yang dikumpulkan dalam kurun waktu 17 tahun (1987-2004). Kasus-kasus tersebut telah dilakukan pemeriksaan analisis fenotipik dan genotipik pada awal diagnosis ditegakkan. Kesemua kasus menunjukkan adanya t(9;22)(q34;q11). Sampel sel-sel mononuklear pasien yang disimpan dalam bentuk 10%DMSO diperiksa Reverse Transkripsi (RT) PCR BCR_ABL multiplex untuk mendeteksi transkrip fusi bcr-abl, PCR CD3ε untuk mendeteksi Cd3 sitoplasmik, dan PCR TdT untuk mendeteksi terminal deoxynucleotidyl transferase. Hasil analisis antigen permukaan sel pada awal diagnosis menunjukkan 1 kasus CD7+, CD5-, dan CD2-; 1 kasus CD7+, CD5+, dan CD2-; dan 2 kasus CD7+, CD5+, dan CD2+ yang menunjukkan bahwa semua sel T krisis blastik CML berada pada stadium pre dan protimik. Dua kasus menunjukkan hasil positip untuk transkrip bcr-abl b2a2, 1 kasus positip pada e1a2, dan 1 kasus negatip. RT PCR CD3ε menunjukkan hasil positip pada semua kasus dan RT PCR TdT hanya positip pada 1 kasus. Hasil yang dikumpulkan diharapkan dapat menjadi dasar analisis lebih lanjut pada kasus CML dengan krisis blastik sel-sel T.

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“…As we have shown, the gene expression of RAG-1 (recombination activating gene-1) is markedly activated at this stage, leading to the most diverse clonal expansion by rearrangement of the TCR-P chain gene [41]. CD21 antigen also begins to be expressed mostly at this stage [42]. A multitude of cellular mechanisms must be pre-pared.…”

Section: Peripheral Prothymic Stagementioning

confidence: 93%

Expression pattern of CD45 RA/RO isoformic antigens in T‐lineage neoplasms

et al. 1995

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The expression of CD45 RA/RO antigen was investigated in neoplasms including cases expressing CD7 antigen as the sole pan-T antigen (n = 8), T-lineage acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL) at various stages of differentiation (n = 32), peripheral stage T-lineage leukemia (n = 10) and adult T-cell leukemia (ATL) (n = 14). The p56lck gene expression was also investigated in selected cases. The expression pattern of CD45 RA/RO antigen was defined as of RA, mixed, or RO type. All but one CD7+ CD5- CD2- case were of the RA type. The CD7+ CD5+ CD2- prothymic stage included seven RA and one mixed type cases. One CD7+ CD5- CD2+ case was of the RA type, but the other was of the RO type. The CD7+ CD5+ CD2+ prothymic stage included three RA and four mixed type cases. All seven CD3- CD4+ CD8+ (double-positive) thymic cases were of the RO type. The CD3+ CD4+ CD8+ (triple-positive) stage included two RO and three mixed-type cases. One CD3+ CD4+ CD8- late thymic case was of the mixed type. The peripheral stage cases included five RA, three RO, and two mixed type cases. All ATL cases were of the RO type. The expression of p56lck gene in the prothymic stage was less marked than that in the thymic stage. On the basis of these results, the following sequence of pattern of the CD45 RA/RO antigen expression along with T-lineage differentiation was reconstructed: prothymic stage [RA and mixed type]-->double-positive thymic stage [RO type]-->triple-positive thymic stage [RO and mixed type]-->peripheral stage [RA, mixed, and RO type]. While one RO-type CD7+ CD5- CD2- and one RO-type CD7+ CD5- CD2+ cases were not in accord with this sequence, the pattern of CD45 RA/RO antigen expression in most of T-lineage neoplasms could be determined by the respective stage of differentiation. The poor expression of the p56lck gene by the prothymic blasts compared with the thymic blasts may be related to the expression pattern of the CD45 RA/RO molecules, which exhibits phosphatase activity. The consistent RO-type expression in the ATL cases may reflect the activated status of the neoplastic T cells due to the presence of the HTLV-I gene. Alternatively, the target cells for HTLV-I-induced neoplastic transformation may possible be of the RO type.

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CD21 antigen in T‐lineage neoplastic lymphoid cells: Characteristic expression at thymic stage

Cited by 9 publications

References 22 publications

Pattern of Epstein–Barr virus association in childhood non‐Hodgkin's lymphoma: Experience of University of Malaya Medical Center

Pattern of Epstein–Barr virus association in childhood non‐Hodgkin's lymphoma: Experience of University of Malaya Medical Center

T-lineage blast crisis of chronic myelogenous leukemia: simple record of 4 cases

Expression pattern of CD45 RA/RO isoformic antigens in T‐lineage neoplasms

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