CD200 Expression in Neuroendocrine Neoplasms

Love, Jason E.; Thompson, Kimberly D.; Kilgore, Mark R.; Westerhoff, Maria; Murphy, Claire; Papanicolau‐Sengos, Antonios; McCormick, Kinsey A.; Shankaran, Veena; Vandeven, Natalie; Miller, Frank C.; Blom, Astrid; Nghiem, Paul; Kussick, Steven J.

doi:10.1093/ajcp/aqx071

Cited by 29 publications

(29 citation statements)

References 26 publications

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“…Analysis of previously published devil and DFT cell transcriptomes suggested that CD200 mRNA is highly expressed in DFT2 cells and peripheral nerves, moderately expressed in DFT1 cells, and lower in other healthy devil tissues (Figure 5A) 34, 35, 39 . As CD200 is an inhibitory molecule expressed on most human neuroendocrine neoplasms 40 , and both DFT1 and DFT2 originated from Schwann cells 35, 41 , we sought to investigate CD200 expression on DFT cells at the protein level. Staining of wild-type DFT1 and DFT2 cells with CD200R1-mOrange FAST protein showed minimal fluorescent signal (Figure 5B).…”

Section: Resultsmentioning

confidence: 99%

“…In addition to high expression of CD200 on neuroendocrine neoplasms 40, 44 , CD200 is used as a diagnostic marker for several human blood cancers 45–47 . DFT cells metastasize in the majority of cases 48 and our transcriptome results (Figure 5A) suggest that CD200 mRNA is more highly expressed in DFT cells than in peripheral blood mononuclear cells (PBMCs) 34, 35 .…”

Section: Resultsmentioning

confidence: 99%

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A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers

Flies

Darby

Lennard

et al. 2019

Preprint

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Immune checkpoint immunotherapy has revolutionized medicine, but translational success for new treatments remains low. Around 40% of humans and Tasmanian devils (Sarcophilus harrisii) develop cancer in their lifetime, compared to less than 10% for most species. Additionally, devils are affected by two of the three known transmissible cancers in mammals. Unfortunately, little is known about of immune checkpoints in devils and other non-model species, largely due to a lack of species-specific reagents. We developed a simple cut-and-paste reagent development method applicable to any vertebrate species and show that immune checkpoint interactions are conserved across 160 million years of evolution. The inhibitory checkpoint molecule CD200 is highly expressed on devil facial tumor cells. We are the first to demonstrate that co-expression of CD200R1 can block CD200 expression. The evolutionarily conserved pathways suggest that naturally occurring cancers in devils and other species can serve as models for understanding cancer and immunological tolerance.GRAPHICAL ABSTRACT

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers

Flies

Darby

Lennard

et al. 2019

Preprint

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“…The exact origin of Merkel cells remains controversial. It has been suggest that these cells originate from one of the neurocrest derivatives [ 39 , 40 , 41 ], keratinocytes, epidermal fibroblasts, early B cells or hair follicle stem cells [ 42 , 43 , 44 , 45 ].…”

Section: Merkel Cell Carcinomamentioning

confidence: 99%

MicroRNAs as Potential Biomarkers in Merkel Cell Carcinoma

Konstantinell

Coucheron

Sveinbjørnsson

et al. 2018

IJMS

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Merkel cell carcinoma (MCC) is a rare and aggressive type of skin cancer associated with a poor prognosis. This carcinoma was named after its presumed cell of origin, the Merkel cell, which is a mechanoreceptor cell located in the basal epidermal layer of the skin. Merkel cell polyomavirus seems to be the major causal factor for MCC because approximately 80% of all MCCs are positive for viral DNAs. UV exposure is the predominant etiological factor for virus-negative MCCs. Intracellular microRNA analysis between virus-positive and virus-negative MCC cell lines and tumor samples have identified differentially expressed microRNAs. Comparative microRNA profiling has also been performed between MCCs and other non-MCC tumors, but not between normal Merkel cells and malignant Merkel cells. Finally, Merkel cell polyomavirus encodes one microRNA, but its expression in virus-positive MCCs is low, or non-detectable or absent, jeopardizing its biological relevance in tumorigenesis. Here, we review the results of microRNA studies in MCCs and discuss the potential application of microRNAs as biomarkers for the diagnosis, progression and prognosis, and treatment of MCC.

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“…These immunohistochemical markers are summarized in Table II. It is worth noting that ttf-1 is typically negative in mcc 12,20,21 . The pd-L1 marker was found to be expressed in 42% to 69% of cases of mcc.…”

Section: Diagnosis and Histologymentioning

confidence: 99%

Merkel Cell Carcinoma Masquerading As Cellulitis: A Case Report and Review of the Literature

Safa¹,

Pant²,

Weerasinghe

et al. 2018

Current Oncology

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Merkel cell carcinoma (mcc) is an uncommon malignancy of the skin arising from cells located in the deeper layers of the epidermis called Merkel cells. This malignancy rarely presents as a metastatic disease, and the field is therefore deficient in regards to management. We report the case of a 49-year-old woman who presented with a presumptive diagnosis of osteomyelitis of the left fifth digit that was resistant to treatment with antibiotics; she underwent debridement of the digit that revealed mcc and was later to have metastatic disease to her lungs, liver, and musculoskeletal system. The management of mcc, although simple in the early stage of the disease, can become challenging when it is more advanced. Multiple new modalities for its treatment have emerged over the last few years, and more recently, clinical trials are being conducted for the use of immunotherapy agents in the treatment of this malignancy.

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CD200 Expression in Neuroendocrine Neoplasms

Cited by 29 publications

References 26 publications

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers

MicroRNAs as Potential Biomarkers in Merkel Cell Carcinoma

Merkel Cell Carcinoma Masquerading As Cellulitis: A Case Report and Review of the Literature

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